INT112612

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 6.35
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Fabp3) cytosol (Fabp3) mitochondrion (Fabp3)
cytoplasm (Fabp3)
Anatomy Link Frequency
heart 3
myocyte 2
blood 2
adipose tissue 1
Fabp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Angina 32 97.08 Very High Very High Very High
Inflammation 3 93.00 High High
metalloproteinase 3 90.00 High High
agonist 48 50.00 Quite Low
isoflurane 1 42.36 Quite Low
anesthesia 1 41.72 Quite Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 13 100.00 Very High Very High Very High
Obesity 6 99.60 Very High Very High Very High
Cv General 3 Under Development 8 98.68 Very High Very High Very High
Left Ventricular Hypertrophy 3 98.52 Very High Very High Very High
Angina 24 97.08 Very High Very High Very High
Natriuresis 3 96.76 Very High Very High Very High
Myocardial Infarction 37 96.48 Very High Very High Very High
Death 12 95.40 Very High Very High Very High
Peripheral Arterial Disease 3 94.40 High High
Vasculitis 3 93.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Diagnostic and prognostic value of heart-type fatty acid-binding protein (H-FABP), an early biochemical marker of myocardial injury].
Gene_expression ([Diagnostic) of H-FABP in heart associated with injury
1) Confidence 0.59 Published 2005 Journal Arch Mal Coeur Vaiss Section Title Doc Link 16435602 Disease Relevance 0.58 Pain Relevance 0.13
Determination of FABP3 mRNA level in white adipose tissue by real time PCR
Gene_expression (level) of FABP3 mRNA in adipose tissue associated with obesity
2) Confidence 0.58 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526775 Disease Relevance 0.26 Pain Relevance 0
[Diagnostic and prognostic value of heart-type fatty acid-binding protein (H-FABP), an early biochemical marker of myocardial injury].
Gene_expression ([Diagnostic) of heart-type fatty acid-binding protein in heart associated with injury
3) Confidence 0.52 Published 2005 Journal Arch Mal Coeur Vaiss Section Title Doc Link 16435602 Disease Relevance 0.58 Pain Relevance 0.13
Specificities of cTnT, CK-MB, myoglobin, H-FABP (by ELISA), H-FABP (by LTIA), and ECG were 98.1%, 71.7%, 81.1%, 77.4%, 90.6%, and 92.5%, respectively.
Gene_expression (Specificities) of H-FABP
4) Confidence 0.42 Published 2010 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 20551280 Disease Relevance 0.40 Pain Relevance 0.08
Patients were assessed on admission for clinical characteristics, electrocardiographic findings, renal function, cardiac troponin T (cTnT), markers of myocyte injury (heart fatty acid-binding protein [H-FABP] and glycogen phosphorylase BB), neurohormonal activation (N-terminal-pro-brain natriuretic peptide [NT-pro-BNP]), hemostatic activity (fibrinogen and D-dimer), and vascular inflammation (high-sensitivity C-reactive protein, myeloperoxidase, matrix metalloproteinase-9, pregnancy-associated plasma protein-A, and soluble CD40 ligand).
Gene_expression (admission) of H-FABP in myocyte associated with natriuresis, inflammation, injury, metalloproteinase and vasculitis
5) Confidence 0.37 Published 2009 Journal Am. J. Cardiol. Section Abstract Doc Link 19101224 Disease Relevance 0.81 Pain Relevance 0.36
On multivariate analysis, H-FABP and NT-pro-BNP were selected, in addition to age, peak cTnT, and left ventricular hypertrophy on initial electrocardiography, as significant independent predictors of death or MI within 1 year.
Gene_expression (selected) of H-FABP associated with left ventricular hypertrophy, myocardial infarction and death
6) Confidence 0.33 Published 2009 Journal Am. J. Cardiol. Section Abstract Doc Link 19101224 Disease Relevance 1.40 Pain Relevance 0.33
Levels of heart-type fatty acid-binding protein >or=6.2 ng/mL were considered as positive results.
Gene_expression (Levels) of heart-type fatty acid-binding protein in heart
7) Confidence 0.32 Published 2003 Journal Am. J. Med. Section Body Doc Link 12935824 Disease Relevance 0.09 Pain Relevance 0
Patients were assessed on admission for clinical characteristics, electrocardiographic findings, renal function, cardiac troponin T (cTnT), markers of myocyte injury (heart fatty acid-binding protein [H-FABP] and glycogen phosphorylase BB), neurohormonal activation (N-terminal-pro-brain natriuretic peptide [NT-pro-BNP]), hemostatic activity (fibrinogen and D-dimer), and vascular inflammation (high-sensitivity C-reactive protein, myeloperoxidase, matrix metalloproteinase-9, pregnancy-associated plasma protein-A, and soluble CD40 ligand).
Gene_expression (admission) of heart fatty acid-binding protein in myocyte associated with natriuresis, inflammation, injury, metalloproteinase and vasculitis
8) Confidence 0.32 Published 2009 Journal Am. J. Cardiol. Section Abstract Doc Link 19101224 Disease Relevance 0.80 Pain Relevance 0.36
In patients presenting <4 h of symptom onset, sensitivity of H-FABP for MI was significantly higher than admission cTnT (73 vs. 55%; P = 0.043).
Gene_expression (sensitivity) of H-FABP
9) Confidence 0.29 Published 2008 Journal Eur. Heart J. Section Body Doc Link 18682444 Disease Relevance 0.14 Pain Relevance 0
METHODS AND RESULTS: Serial blood samples were taken soon after arrival in an emergency department in 74 patients with suspected acute coronary syndrome to quantify blood levels of troponin-T (TnT), heart-type fatty acid-binding protein (H-FABP), myocardial-bound creatine kinase (CK-MB), and myoglobin.
Gene_expression (levels) of H-FABP in blood
10) Confidence 0.26 Published 2006 Journal Circ. J. Section Body Doc Link 16565558 Disease Relevance 0.27 Pain Relevance 0
METHODS AND RESULTS: Serial blood samples were taken soon after arrival in an emergency department in 74 patients with suspected acute coronary syndrome to quantify blood levels of troponin-T (TnT), heart-type fatty acid-binding protein (H-FABP), myocardial-bound creatine kinase (CK-MB), and myoglobin.
Gene_expression (levels) of heart-type fatty acid-binding protein in blood
11) Confidence 0.22 Published 2006 Journal Circ. J. Section Body Doc Link 16565558 Disease Relevance 0.27 Pain Relevance 0
Specificities of cTnT, CK-MB, myoglobin, H-FABP (by ELISA), H-FABP (by LTIA), and ECG were 98.1%, 71.7%, 81.1%, 77.4%, 90.6%, and 92.5%, respectively.
Gene_expression (Specificities) of H-FABP
12) Confidence 0.19 Published 2010 Journal Am. J. Clin. Pathol. Section Abstract Doc Link 20551280 Disease Relevance 0.40 Pain Relevance 0.08
METHOD: Serum levels of hs-CRP, h-FABP, cardiac troponin-I (cTn-I) and creatine kinase MB isoenzyme (CK-MB) were measured and cardiac accidents within 2 weeks after the test were observed in 74 patients (male 45) with stable AP (SAP) and 56 patients (male 29) with UAP.
Gene_expression (levels) of h-FABP
13) Confidence 0.13 Published 2006 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 17217689 Disease Relevance 0.20 Pain Relevance 0
The serum hs-CRP and h-FABP levels for patients with cardiac accidents in the SAP group were (6.32 +/- 2.06) microg/L and (8.76 +/- 3.83) microg/L respectively, which were higher than those for the patients having no cardiac accidents in the control (P < 0.01).
Gene_expression (levels) of h-FABP
14) Confidence 0.13 Published 2006 Journal Zhonghua Xin Xue Guan Bing Za Zhi Section Body Doc Link 17217689 Disease Relevance 0.14 Pain Relevance 0

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