INT112620

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Context Info
Confidence 0.16
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.11
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk9) intracellular (Tnf) extracellular matrix organization (Tnf)
cytoplasm (Mapk9) cytosol (Mapk9) signal transduction (Tnf)
Anatomy Link Frequency
joint 1
Mapk9 (Rattus norvegicus)
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 5 98.56 Very High Very High Very High
cytokine 1 94.52 High High
cINOD 1 78.04 Quite High
palliative 1 75.72 Quite High
Arthritis 1 42.48 Quite Low
Disease Link Frequency Relevance Heat
Stress 1 99.36 Very High Very High Very High
Rheumatoid Arthritis 5 98.56 Very High Very High Very High
Disease 5 96.78 Very High Very High Very High
Necrosis 1 94.98 High High
Cancer 1 94.80 High High
Death 1 87.96 High High
INFLAMMATION 1 77.40 Quite High
Arthritis 1 42.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta) are implicated in the disease onset and in the progression of bone and joint destruction that characterizes chronic RA. p38 is an intracellular mitogen/stress-activated protein kinase (MAPK/SAPK) that regulates both the release and the actions of TNF-alpha and IL-1 beta.
SAPK Regulation (regulates) of TNF-alpha in joint associated with stress, necrosis, cancer, rheumatoid arthritis, disease and cytokine
1) Confidence 0.16 Published 2000 Journal Drug News Perspect. Section Abstract Doc Link 12937622 Disease Relevance 1.11 Pain Relevance 0.36

General Comments

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