INT112640

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.26
Pain Relevance 2.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal root ganglia 2
Nav1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nav1.8 9 100.00 Very High Very High Very High
Nav1.2 4 100.00 Very High Very High Very High
nav1.3 4 100.00 Very High Very High Very High
Cancer pain 2 100.00 Very High Very High Very High
Pain 10 99.80 Very High Very High Very High
agonist 1 98.12 Very High Very High Very High
Nav1.9 1 97.12 Very High Very High Very High
sodium channel 12 90.64 High High
Action potential 6 89.92 High High
Nav1.1 2 89.04 High High
Disease Link Frequency Relevance Heat
Cancer Pain 2 100.00 Very High Very High Very High
Breast Cancer 1 98.72 Very High Very High Very High
Cancer 1 96.60 Very High Very High Very High
Pain 4 95.80 Very High Very High Very High
Metastasis 1 93.52 High High
Nerve Compression Syndromes 31 82.24 Quite High
Injury 40 81.60 Quite High
Ganglion Cysts 36 76.40 Quite High
Wallerian Degeneration 1 54.64 Quite High
Hypersensitivity 5 45.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bilateral downregulation of Nav1.8 in dorsal root ganglia of rats with bone cancer pain induced by inoculation with Walker 256 breast tumor cells.
Positive_regulation (induced) of Negative_regulation (downregulation) of Nav1 in dorsal root ganglia associated with pain, cancer pain, breast cancer and nav1.8
1) Confidence 0.50 Published 2010 Journal BMC Cancer Section Title Doc Link 20482896 Disease Relevance 0.58 Pain Relevance 1.18
Nimodipine treatment caused a moderate reduction (approximately 30%) of the mRNA for Nav1.2 and a marked reduction (approximately 70%) of the mRNA for Nav1.3, whereas treatment with Bay K 8644 produced 90-130% increases in these same mRNAs.
Positive_regulation (caused) of Negative_regulation (reduction) of Nav1 associated with nav1.3 and nav1.2
2) Confidence 0.47 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941467 Disease Relevance 0 Pain Relevance 1.12
Nav1.5 exhibits faster kinetics than Nav1.8 and is significantly more sensitive to TTX (IC50 ~2 ?
Positive_regulation (sensitive) of Negative_regulation (exhibits) of Nav1 associated with nav1.8
3) Confidence 0.34 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.69 Pain Relevance 0.69

General Comments

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