INT11266

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Context Info
Confidence 0.43
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (UMOD) extracellular region (UMOD) Golgi apparatus (UMOD)
plasma membrane (UMOD)
Anatomy Link Frequency
kidney 1
UMOD (Homo sapiens)
Pain Link Frequency Relevance Heat
Codeine 6 99.90 Very High Very High Very High
Morphine 7 92.16 High High
Pain 3 83.60 Quite High
Dopamine 1 54.40 Quite High
addiction 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
psoriasis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 4 100.00 Very High Very High Very High
Disease 10 87.48 High High
Hypertension 21 83.92 Quite High
Pain 2 83.60 Quite High
Herpes Zoster 1 82.64 Quite High
Diabetes Mellitus 16 80.12 Quite High
Stroke 3 79.52 Quite High
Intracranial Embolism 1 76.00 Quite High
Chronic Renal Failure 49 50.00 Quite Low
Kidney Stones 19 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings, demonstrating not only the effect of age on UMOD-associated increase in SCr but also the effect of age-related comorbid conditions, may explain why no association was observed between rs4293393-T and kidney function in the Dutch sample set of healthy population-based subjects with much lower SCr values and of much less variability than observed in the Icelandic samples (Figure S3).


Positive_regulation (increase) of UMOD in kidney
1) Confidence 0.43 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2912386 Disease Relevance 0.58 Pain Relevance 0
In contrast, the urinary levels of codeine and THP in L-dopa-treated parkinsonian patients were significantly elevated to 62.20 +/- 17.54 and 31.04 +/- 15.69 pmol/ml, respectively.
Positive_regulation (elevated) of THP associated with parkinson's disease and codeine
2) Confidence 0.41 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1545408 Disease Relevance 0.68 Pain Relevance 1.16

General Comments

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