INT112665

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Context Info
Confidence 0.29
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 3.97
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRAF2) signal transduction (TRAF2) enzyme binding (TRAF2)
protein complex assembly (TRAF2) ligase activity (TRAF2) cytoplasm (TRAF2)
TRAF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 95.84 Very High Very High Very High
Angina 1 95.04 Very High Very High Very High
rheumatoid arthritis 8 94.48 High High
spinal inflammation 1 92.96 High High
Inflammatory marker 2 75.08 Quite High
cytokine 7 57.76 Quite High
alcohol 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 19 100.00 Very High Very High Very High
Necrosis 9 100.00 Very High Very High Very High
Cardiovascular Disease 11 99.64 Very High Very High Very High
Congenital Anomalies 3 98.32 Very High Very High Very High
INFLAMMATION 10 95.84 Very High Very High Very High
Increased Venous Pressure Under Development 1 95.68 Very High Very High Very High
Cv General 3 Under Development 1 95.04 Very High Very High Very High
Rheumatoid Arthritis 8 94.48 High High
Shigella Infection 6 94.48 High High
Systemic Lupus Erythematosus 1 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also in support of this hypothesis, there was no change in expression of JUN, BIRC2/cIAP1, TRAF2, or NFKB2.
Gene_expression (expression) of TRAF2
1) Confidence 0.29 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.41 Pain Relevance 0
Interestingly, TRAF2 was induced in WTSTS, and this induction was not seen in the U versus WT comparison.
Gene_expression (induced) of TRAF2
2) Confidence 0.25 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.42 Pain Relevance 0
The presence of the TNF2 allele has also been linked to increased susceptibility to and severity in a variety of autoimmune and inflammatory disorders, including RA, systemic lupus erythematosus, and ankylosing spondylitis.
Gene_expression (presence) of TNF2 associated with spinal inflammation, inflammation, rheumatoid arthritis and systemic lupus erythematosus
3) Confidence 0.07 Published 2006 Journal Immunobiology Section Abstract Doc Link 16446172 Disease Relevance 1.26 Pain Relevance 0.44
Serum levels of interleukin (IL)-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, and the soluble receptors IL-6 soluble receptor, IL-2 soluble receptor, TNF soluble receptor I, and TNF soluble receptor II were assessed.
Gene_expression (levels) of TNF soluble receptor II associated with necrosis and cancer
4) Confidence 0.00 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 12943870 Disease Relevance 1.87 Pain Relevance 0.17

General Comments

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