INT112668

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.80
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Agtr2) transcription factor binding (Agtr2) signal transducer activity (Agtr2)
Anatomy Link Frequency
adipose tissue 2
Agtr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 12 99.98 Very High Very High Very High
Inflammation 14 95.72 Very High Very High Very High
Chronic pancreatitis 3 90.16 High High
agonist 18 88.80 High High
fibrosis 5 88.16 High High
Sciatic nerve 3 81.40 Quite High
antagonist 12 76.24 Quite High
pulpitis 1 75.00 Quite High
cytokine 2 73.40 Quite High
Kinase C 25 67.72 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 99.98 Very High Very High Very High
Obesity 38 99.52 Very High Very High Very High
Hypertension 2 99.44 Very High Very High Very High
Stomach Cancer 1 99.28 Very High Very High Very High
Cancer 60 99.20 Very High Very High Very High
Cv General 4 Under Development 15 98.84 Very High Very High Very High
Increased Venous Pressure Under Development 6 98.18 Very High Very High Very High
INFLAMMATION 12 95.72 Very High Very High Very High
Insulin Resistance 8 95.00 High High
Apoptosis 21 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the literature AT2-receptor mediated actions on vascular tone have been reported in terms of vasodilation and decrease of arterial pressure and particularly so during pathological conditions with increased AT2 receptor expression [2,17] eg in hypertensive states [18].
Positive_regulation (increased) of Gene_expression (expression) of AT2 associated with hypertension and increased venous pressure under development
1) Confidence 0.50 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0.20 Pain Relevance 0.12
rtPCR AT1 and AT2 receptors
Positive_regulation (rtPCR) of Gene_expression (receptors) of AT2
2) Confidence 0.36 Published 2003 Journal BMC Pharmacol Section Body Doc Link PMC153509 Disease Relevance 0 Pain Relevance 0
The high dose enhanced the expression of angiotensinogen and angiotensin II receptor type 2 mRNA and suppressed the overexpression of transforming growth factor-beta1 mRNA.
Positive_regulation (enhanced) of Gene_expression (expression) of angiotensin II receptor type 2 mRNA
3) Confidence 0.30 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12944495 Disease Relevance 0.74 Pain Relevance 0.65
AT2R expression is low in most adult tissues [37], but is frequently up-regulated in patients with gastric cancer [38].
Positive_regulation (up-regulated) of Gene_expression (expression) of AT2R associated with stomach cancer
4) Confidence 0.18 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2902462 Disease Relevance 1.01 Pain Relevance 0
Recent studies have shown increased expression of angiotensin II-forming enzymes in adipose tissue, and increased activity of the renin-angiotensin system has been implicated in the development of insulin resistance and type 2 diabetes [3].
Positive_regulation (increased) of Gene_expression (expression) of angiotensin II-forming in adipose tissue associated with diabetes mellitus, obesity and insulin resistance
5) Confidence 0.17 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 0.57 Pain Relevance 0.10
Our group has previously shown that in addition to an ischemia-induced endothelin receptor upregulation, there is an alteration in the vascular angiotensin II receptor response after experimental cerebral ischemia [27].
Positive_regulation (induced) of Gene_expression (upregulation) of angiotensin II receptor associated with cv general 4 under development and ischemia
6) Confidence 0.15 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1770924 Disease Relevance 0.75 Pain Relevance 0.35
The AT2 receptor expression was up-regulated by a 9-hour period, and then decreased between 12- and 24-hour periods.
Positive_regulation (up-regulated) of Gene_expression (expression) of AT2 receptor
7) Confidence 0.15 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17197045 Disease Relevance 0.54 Pain Relevance 0.35

General Comments

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