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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.29
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Pdyn) plasma membrane (Pdyn)
Anatomy Link Frequency
cleavage 1
Pdyn (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 15 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
Enkephalin 11 98.24 Very High Very High Very High
Arthritis 3 95.84 Very High Very High Very High
Spinal cord 4 93.84 High High
orphanin 4 72.84 Quite High
Substantia nigra 1 70.40 Quite High
Nucleus accumbens 1 68.72 Quite High
Inflammation 1 67.12 Quite High
Endogenous opioid 1 60.32 Quite High
Disease Link Frequency Relevance Heat
Experimental Arthritis 1 95.84 Very High Very High Very High
Arthritis 2 75.00 Quite High
INFLAMMATION 1 67.12 Quite High
Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The significantly lower ratio between Leu-enkephalin-Arg(6) and dynorphin B in diestrus than in proestrus and estrus also indicates cyclic fluctuations in the enzymatic cleavage of dynorphin.
Protein_catabolism (cleavage) of dynorphin in cleavage associated with dynorphin and enkephalin
1) Confidence 0.45 Published 2006 Journal Neuropeptides Section Abstract Doc Link 16540166 Disease Relevance 0 Pain Relevance 1.06
The enzyme resembles a neutral cysteine endopeptidase which cleaves the opioid peptide dynorphin B and generates its N-terminal fragment, Leu-enkephalin-Arg6 with opioid activity.
Protein_catabolism (cleaves) of dynorphin B associated with dynorphin, enkephalin and opioid
2) Confidence 0.27 Published 1992 Journal Life Sci. Section Abstract Doc Link 1545665 Disease Relevance 0.29 Pain Relevance 0.83
Limited proteolysis of the dynorphin precursor (prodynorphin) at dibasic and monobasic processing sites results in the generation of bioactive dynorphins.
Protein_catabolism (proteolysis) of dynorphin precursor associated with dynorphin
3) Confidence 0.05 Published 1999 Journal J. Biochem. Section Abstract Doc Link 10050055 Disease Relevance 0 Pain Relevance 0.19

General Comments

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