INT112676

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Context Info
Confidence 0.31
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 2.98
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
coronary artery 2
monocytes 2
platelets 2
blood cells 2
tf (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 5 97.76 Very High Very High Very High
Angina 8 92.68 High High
agonist 28 90.04 High High
cytokine 10 61.68 Quite High
Inflammation 20 53.60 Quite High
cva 1 25.00 Low Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
Tetrahydrobiopterin 3 5.00 Very Low Very Low Very Low
Crohn's disease 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 22 99.40 Very High Very High Very High
Disorder Of Lipid Metabolism 137 99.12 Very High Very High Very High
Adhesions 18 95.32 Very High Very High Very High
Thrombosis 6 93.68 High High
Death 8 93.40 High High
Cv General 3 Under Development 8 92.68 High High
Hemolytic Uremic Syndrome 123 91.52 High High
Increased Venous Pressure Under Development 9 85.64 High High
Injury 9 74.40 Quite High
Endotoxemia 12 66.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Higher neutrophil counts may form more aggregates with platelets leading to more TF release, which may, in part, explain why neutrophilia is associated with a worse prognosis.
Positive_regulation (leading) of Localization (release) of TF in platelets
1) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.73 Pain Relevance 0
This process promoted the release of TF-bearing microparticles from activated blood cells.
Positive_regulation (promoted) of Localization (release) of TF in blood cells
2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.37 Pain Relevance 0.09
1) Stx2, both LPS serotypes tested and Stx2/LPS induced increased release of functional TF into plasma in comparison to unstimulated- (Table 3) or PBS- treated whole blood (data not shown).
Positive_regulation (increased) of Localization (release) of TF in blood
3) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.31 Pain Relevance 0.13
In contrast to atherogenic lipoproteins, like LDL and very low-density lipoprotein (VLDL), which stimulate both the secretion of tissue factor (TF) and the activation of extrinsic tenase, HDL per se does not stimulate the secretion of TF from endothelial cells or monocytes (Kaneko et al 1994).
Positive_regulation (activation) of Localization (secretion) of TF in monocytes associated with disorder of lipid metabolism
4) Confidence 0.14 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.16 Pain Relevance 0
These data suggest reduced release of circulating TF by combined anti-platelet therapy with ticlopidine and aspirin after coronary artery stenting, which may-contribute to the lower incidence of subacute stent thrombosis previously observed.
Positive_regulation (circulating) of Localization (release) of TF in coronary artery associated with aspirin and thrombosis
5) Confidence 0.08 Published 2003 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 12945880 Disease Relevance 0.41 Pain Relevance 0.43

General Comments

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