INT112684

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Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 3.48
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
jejunum 2
corneas 2
neutrophil 2
eye 1
plasma 1
Cor (Mus musculus)
Pain Link Frequency Relevance Heat
Transcranial magnetic stimulation 2 100.00 Very High Very High Very High
Pain 9 99.22 Very High Very High Very High
cINOD 54 98.68 Very High Very High Very High
fluoxetine 2 98.36 Very High Very High Very High
Eae 3 94.24 High High
Adelta 1 93.56 High High
Inflammation 191 88.80 High High
depression 5 87.04 High High
cytokine 38 86.36 High High
Bioavailability 1 86.12 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 2 100.00 Very High Very High Very High
Chemical Burns 36 99.98 Very High Very High Very High
Pain 6 99.22 Very High Very High Very High
Injury 27 98.04 Very High Very High Very High
Diabetes Mellitus 136 97.88 Very High Very High Very High
Gastritis 6 97.88 Very High Very High Very High
Anxiety Disorder 3 97.52 Very High Very High Very High
Prediabetic State 36 97.48 Very High Very High Very High
Insulin Resistance 50 97.32 Very High Very High Very High
Peptic Ulcer 9 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, the synergistic importance regarding elevations of both glucose and native LDL-C or mmLDL which result in elevations of the detrimental superoxide (O2') can uncouple the eNOS enzyme leading to even further increases in O2'.
Positive_regulation (elevations) of C or
1) Confidence 0.45 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 0.92 Pain Relevance 0.09
The result of our study showed COR in the jejunum was not elevated despite using a higher dosage of rebamipide.
Neg (not) Positive_regulation (elevated) of COR in jejunum
2) Confidence 0.29 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966936 Disease Relevance 0.35 Pain Relevance 0.15
The mean COR level was higher in the 200 mg group than in the 100 mg group.


Positive_regulation (higher) of COR
3) Confidence 0.27 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966936 Disease Relevance 0.06 Pain Relevance 0.06
However, the mean COR levels in the jejunum were not elevated despite administration of 200 mg of rebamipide.
Neg (not) Positive_regulation (elevated) of COR in jejunum
4) Confidence 0.27 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2966936 Disease Relevance 0.36 Pain Relevance 0.09
Experiment 3 found that group-housed females had higher baseline corticosterone (CORT) levels than isolated females and fluoxetine had no effect on CORT levels.
Positive_regulation (had) of corticosterone associated with fluoxetine
5) Confidence 0.15 Published 2010 Journal Behav. Brain Res. Section Abstract Doc Link 19819265 Disease Relevance 0.71 Pain Relevance 0.49
We report on the silencing of codeinone reductase (COR) in the opium poppy, Papaver somniferum, using a chimeric hairpin RNA construct designed to silence all members of the multigene COR family through RNA interference (RNAi).
Positive_regulation (silencing) of COR
6) Confidence 0.14 Published 2004 Journal Nat. Biotechnol. Section Abstract Doc Link 15543134 Disease Relevance 0.08 Pain Relevance 0.22
It indicated that when cumulative EA analgesia appeared, in CCI animals, only plasma COR level increased pronouncedly, while in OVX + CCI rats, both plasma beta-EP and COR contents decreased evidently.
Positive_regulation (increased) of COR in plasma
7) Confidence 0.13 Published 2007 Journal Zhen Ci Yan Jiu Section Body Doc Link 18050621 Disease Relevance 0 Pain Relevance 0
These cDNAs were used together with previously isolated clones for tyrosine/dopa decarboxylase (TYDC), (S)-N-methylcoclaurine-3'-hydroxylase (CYP80B1), berberine bridge enzyme, (BBE), (7S)-salutaridinol 7-O-acetyltransferase (SAT), and codeinone reductase (COR), to compare the accumulation of gene transcripts encoding eight alkaloid biosynthetic enzymes in opium poppy.
Positive_regulation (accumulation) of COR in bridge
8) Confidence 0.06 Published 2003 Journal Phytochemistry Section Abstract Doc Link 12946416 Disease Relevance 0 Pain Relevance 0.13
Upregulation of S100A gene expression in corneas upon CorNV induction
Positive_regulation (induction) of CorNV in corneas
9) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.09 Pain Relevance 0
To deplete neutrophils in vivo and study the effect on CorNV pathogenesis, purified anti-mouse Gr-1 antibody (RB6–8C5; eBioscience, San Diego, CA) was injected intraperitoneally (0.5 mg in 0.2 ml per mouse) [21] every other day starting one day before S-CorNV induction.
Positive_regulation (induction) of CorNV in neutrophils
10) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0 Pain Relevance 0
For the extraction of total RNA used for either microarray analysis or RT-QPCR, the corneas were excised using a 2 mm diameter trepan and placed in ice-cold TRIzol reagent (Invitrogen, Gaithersburg, MD) at desired time points after CorNV induction.
Positive_regulation (induction) of CorNV in corneas
11) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.16 Pain Relevance 0
Only the right eye of each mouse was used for CorNV induction.
Positive_regulation (induction) of CorNV in eye
12) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.27 Pain Relevance 0.15
In our pilot studies, we found that S-CorNV developed rapidly around day 5 and peaked around day 10, while CB-induced CorNV reached similar levels at days 6 and 14, respectively.
Positive_regulation (induced) of CorNV associated with chemical burns
13) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0.10 Pain Relevance 0
Suture CorNV induction and molecular studies of the neutrophil-depleted mice were performed as described above to study the potential effect of neutrophil depletion on the development of S-CorNV.


Positive_regulation (induction) of CorNV in neutrophil
14) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2994359 Disease Relevance 0 Pain Relevance 0
Modulation of electrically induced pain by paired pulse transcranial magnetic stimulation of the medial frontal cortex.
Positive_regulation (stimulation) of medial frontal cortex in frontal cortex associated with pain, transcranial magnetic stimulation and urological neuroanatomy
15) Confidence 0.00 Published 2006 Journal Clin Neurophysiol Section Title Doc Link 16807095 Disease Relevance 0.39 Pain Relevance 0.44

General Comments

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