INT112689

Context Info Confidence 0.59 First Reported 2003 Last Reported 2010 Negated 0 Speculated 1 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.45 Pain Relevance 0.44

phosphatase activity (Ptpn2) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2) cytoplasm (Ptpn2)

Ptpn2 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 2 99.04 agonist 4 95.12 algil 3 93.64 Inflammation 42 78.36 cINOD 27 13.04 Dopamine 21 5.00 midbrain 12 5.00 cytokine 8 5.00 Inflammatory mediators 4 5.00 COX-2 inhibitor 3 5.00

Disease Link Frequency Relevance Heat Parkinson's Disease 112 100.00 Body Weight 1 99.52 Pain 2 99.04 Toxicity 16 96.32 INFLAMMATION 52 78.36 Aging 18 43.20 Disease 35 40.76 Drug Induced Neurotoxicity 10 25.12 Injury 6 5.00 Experimental Autoimmune Encephalomyelitis 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MPTP administration

Protein_catabolism (administration) of MPTP associated with parkinson's disease

1) Confidence 0.59 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.90 Pain Relevance 0.04

A possible hydrolytic degradation of an ester group can generate a very toxic compound, the N-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) which contaminates the drug.

Spec (possible) Protein_catabolism (degradation) of MPTP associated with parkinson's disease

2) Confidence 0.37 Published 2003 Journal J Pharm Biomed Anal Section Abstract Doc Link 12946525 Disease Relevance 0.55 Pain Relevance 0.40

General Comments

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