INT112689

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

phosphatase activity (Ptpn2) endoplasmic reticulum (Ptpn2) nucleus (Ptpn2)
cytoplasm (Ptpn2)
Ptpn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 2 99.04 Very High Very High Very High
agonist 4 95.12 Very High Very High Very High
algil 3 93.64 High High
Inflammation 42 78.36 Quite High
cINOD 27 13.04 Low Low
Dopamine 21 5.00 Very Low Very Low Very Low
midbrain 12 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 112 100.00 Very High Very High Very High
Body Weight 1 99.52 Very High Very High Very High
Pain 2 99.04 Very High Very High Very High
Toxicity 16 96.32 Very High Very High Very High
INFLAMMATION 52 78.36 Quite High
Aging 18 43.20 Quite Low
Disease 35 40.76 Quite Low
Drug Induced Neurotoxicity 10 25.12 Quite Low
Injury 6 5.00 Very Low Very Low Very Low
Experimental Autoimmune Encephalomyelitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MPTP administration
Protein_catabolism (administration) of MPTP associated with parkinson's disease
1) Confidence 0.59 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.90 Pain Relevance 0.04
A possible hydrolytic degradation of an ester group can generate a very toxic compound, the N-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP) which contaminates the drug.
Spec (possible) Protein_catabolism (degradation) of MPTP associated with parkinson's disease
2) Confidence 0.37 Published 2003 Journal J Pharm Biomed Anal Section Abstract Doc Link 12946525 Disease Relevance 0.55 Pain Relevance 0.40

General Comments

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