INT112693

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.17
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bax) endoplasmic reticulum (Bax) intracellular (Bax)
cytoplasm (Bax) cytosol (Bax) cell proliferation (Bax)
Anatomy Link Frequency
poly 1
cleavage 1
eosinophil 1
Bax (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 2 99.22 Very High Very High Very High
cytokine 42 96.20 Very High Very High Very High
Inflammation 37 95.80 Very High Very High Very High
Paracetamol 8 93.16 High High
Spinal cord 81 89.44 High High
Inflammatory mediators 1 82.68 Quite High
chemokine 5 66.36 Quite High
aspirin 13 53.24 Quite High
imagery 14 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 164 99.56 Very High Very High Very High
INFLAMMATION 43 95.80 Very High Very High Very High
Injury 39 92.88 High High
Myelitis 1 89.96 High High
Spinal Cord Injury 122 87.32 High High
Pressure And Volume Under Development 2 80.00 Quite High
Ovarian Cancer 33 77.28 Quite High
Targeted Disruption 8 73.68 Quite High
Breast Cancer 13 68.76 Quite High
Asthma 24 62.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The caspase inhibitor failed to prevent both the redistribution of Bax to the mitochondria and the loss of cytochrome c.
Protein_catabolism (redistribution) of Bax
1) Confidence 0.74 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12946648 Disease Relevance 0.63 Pain Relevance 0.57
B expression, (6) p-ERK1/2 and p38 expression and (7) apoptosis (TUNEL staining, FAS ligand, Bax and Bcl-2 expression).
Protein_catabolism (ligand) of Bax associated with apoptosis
2) Confidence 0.46 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935363 Disease Relevance 1.48 Pain Relevance 0.33
These effects are mirrored by the abrogation of the increase in p21 levels in the nucleus and the lack of Bax cleavage in response to TNFalpha.
Protein_catabolism (cleavage) of Bax in cleavage
3) Confidence 0.45 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.40 Pain Relevance 0.04
Nasal explants from atopic patients were shown to survive ex vivo using similar mechanisms to promote extramedullary eosinophil maturation and survival.83 These, as well as lung explants of Brown-Norway rats, exhibited rapid (6 hours) accumulation of MBP-positive cells after allergen challenge of the explants in vitro.86 The major signaling pathway of these events is associated with IL-5 receptor ligation leading to phosphorylation of JAK-2 and Lyn kinases, decreased BAX translocation, and ultimately decreased apoptosis.87 Additionally, GM-CSF appears to have a strong role in inhibiting eosinophil apoptosis at the tissue level.
Protein_catabolism (translocation) of BAX in eosinophil associated with apoptosis
4) Confidence 0.13 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.45 Pain Relevance 0.16
Antibodies for pEGFR (Tyr845, Tyr992), EGFR, pSTAT3 (Tyr705 and Ser727), poly-adenosine diphosphate ribose polymerase (PARP), cleaved caspases-3, Bcl-xL, and Bax were purchased from Cell Signaling Technology (Beverly, MA).
Protein_catabolism (cleaved) of Bax in poly associated with adenocard
5) Confidence 0.07 Published 2008 Journal J Transl Med Section Body Doc Link PMC2267444 Disease Relevance 0.21 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox