INT112694

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.30
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fas) extracellular region (Fas) plasma membrane (Fas)
nucleus (Fas) cytoplasm (Fas)
Anatomy Link Frequency
brain 2
T cell 2
Fas (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 40 99.56 Very High Very High Very High
Paracetamol 8 98.08 Very High Very High Very High
Infliximab 17 64.32 Quite High
chemokine 3 60.48 Quite High
rheumatoid arthritis 12 58.00 Quite High
Inflammation 34 57.60 Quite High
Etanercept 18 56.00 Quite High
tolerance 20 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 212 99.24 Very High Very High Very High
Death 103 98.60 Very High Very High Very High
Lymphadenopathy 15 98.48 Very High Very High Very High
Lymphoproliferative Disease 5 94.24 High High
Injury 11 93.04 High High
Graft Vs Host Disease 3 90.32 High High
Autoimmune Lymphoproliferative Syndrome 1 89.24 High High
Systemic Lupus Erythematosus 75 88.76 High High
Autoimmune Disease 68 88.00 High High
Stress 85 75.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FasL and Fas have been implicated because activation-induced cell death (AICD), an in vitro model in which mitogen-activated T cell blasts are killed by TCR restimulation, which causes FasL upregulation, is inhibited by FasL or Fas inactivation (Brunner et al., 1995; Dhein et al., 1995; Russell et al., 1993).
Negative_regulation (inhibited) of Positive_regulation (inactivation) of Fas in T cell associated with death
1) Confidence 0.42 Published 2008 Journal Immunity Section Body Doc Link PMC2270348 Disease Relevance 0.94 Pain Relevance 0.04
Six hours after AAP administration to BALB/c mice, a significant loss of hepatic mitochondrial cytochrome c was observed that was similar in extent to the loss observed after in vivo activation of CD95 by antibody treatment.
Negative_regulation (loss) of Positive_regulation (activation) of CD95 associated with paracetamol
2) Confidence 0.37 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12946648 Disease Relevance 0.33 Pain Relevance 0.53
Fas/Fas ligand (FasL; CD178) are deficient in autoimmune lpr and gld mice, which develop profound lymphadenopathies.
Negative_regulation (deficient) of Positive_regulation (autoimmune) of lpr associated with lymphadenopathy
3) Confidence 0.21 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 1.84 Pain Relevance 0.18
In that model the authors showed that in vivo blockade of TNF alpha preferentially inhibited the production of interferon gamma and blocked interferon-gamma-dependent upregulation of Fas; and that cytokines such as IL-10, IL-6, or IL-4 were not inhibited.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of Fas associated with cytokine
4) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174953 Disease Relevance 0.81 Pain Relevance 0.14
The model presented in Figure 4 indicates that mitochondria play a significant role in the amplification of the apoptotic processes initiated by growth factor deprivation, DD receptors activation (p75 and Fas), increased levels of intracellular Ca2+ linked to excitotoxicity and ROS accumulation in response to the many brain insults.

6.4.

Negative_regulation (deprivation) of Positive_regulation (activation) of Fas in brain associated with apoptosis
5) Confidence 0.12 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.37 Pain Relevance 0

General Comments

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