INT112698

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 6.52
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bid) mitochondrion (Bid) cytoplasm (Bid)
Anatomy Link Frequency
cleavage 2
Bid (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 16 99.22 Very High Very High Very High
Morphine 6 89.92 High High
withdrawal 3 88.56 High High
antagonist 10 81.68 Quite High
palliative 1 62.08 Quite High
anesthesia 14 5.00 Very Low Very Low Very Low
isoflurane 9 5.00 Very Low Very Low Very Low
imagery 9 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 8 99.96 Very High Very High Very High
Apoptosis 153 99.78 Very High Very High Very High
Death 33 99.32 Very High Very High Very High
Pancreatic Cancer 6 98.64 Very High Very High Very High
Epstein-barr Virus 58 92.68 High High
Severe Combined Immunodeficiency 2 92.56 High High
Cancer 278 92.24 High High
Follicular Lymphoma 4 90.12 High High
Nasopharynx Cancer 6 86.32 High High
Lymphatic System Cancer 18 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases.
Gene_expression (roles) of Bid associated with paracetamol, injury and apoptosis
1) Confidence 0.64 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 12946648 Disease Relevance 0.51 Pain Relevance 0.61
At the same time, tBid became detectable in the mitochondrial fraction, and concomitantly, Bax was found translocated to mitochondria.
Gene_expression (detectable) of tBid
2) Confidence 0.50 Published 2003 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12946648 Disease Relevance 0.43 Pain Relevance 0.57
Full-length Bid (22 kDa) was detected in control cells and in cells treated with raloxifene for 48 h (Figure 2D).
Gene_expression (detected) of Bid
3) Confidence 0.44 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.29 Pain Relevance 0
However, since Bid cleavage was not observed, cross-talk between caspase-8 and Bid may not be involved.
Gene_expression (cleavage) of Bid in cleavage
4) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.90 Pain Relevance 0
Bid cleavage
Gene_expression (cleavage) of Bid in cleavage
5) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2978204 Disease Relevance 0.35 Pain Relevance 0
No changes on t-Bid expression were detected under any experimental condition.
Gene_expression (expression) of t-Bid
6) Confidence 0.36 Published 2006 Journal J. Neurosci. Res. Section Abstract Doc Link 16496378 Disease Relevance 0.45 Pain Relevance 0.58
Caspase-8 and Bid were cleaved in Colo357 cells exposed to gemcitabine, and there was no correlation with either Bcl-xL or with Bax expression.
Gene_expression (cleaved) of Bid
7) Confidence 0.34 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 14750167 Disease Relevance 1.44 Pain Relevance 0.10
In addition to the pro-apoptotic BH3-only protein Bim, its key target in lymphoid cells, BHRF1 also binds a selective sub-set of pro-apoptotic proteins (Bid, Puma, Bak) expressed by host cells.
Gene_expression (expressed) of Bid associated with apoptosis
8) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC3009601 Disease Relevance 0.72 Pain Relevance 0.04
BHRF1 is known to bind the pro-apoptotic BH3-only protein Bim, and here we demonstrate that it also binds other pro-apoptotic proteins (Bid, Puma, Bak) expressed by host cells.
Gene_expression (expressed) of Bid associated with apoptosis
9) Confidence 0.14 Published 2010 Journal PLoS Pathogens Section Abstract Doc Link PMC3009601 Disease Relevance 1.44 Pain Relevance 0.07

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