INT1127

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Context Info
Confidence 0.28
First Reported 1976
Last Reported 2011
Negated 2
Speculated 1
Reported most in Abstract
Documents 32
Total Number 33
Disease Relevance 21.10
Pain Relevance 7.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
plasma 2
B cells 2
T cell 2
spinal 1
capillary 1
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 10 100.00 Very High Very High Very High
Multiple sclerosis 53 99.76 Very High Very High Very High
Morphine 9 99.76 Very High Very High Very High
agonist 9 99.76 Very High Very High Very High
intrathecal 2 99.76 Very High Very High Very High
Inflammation 48 99.72 Very High Very High Very High
narcan 2 99.52 Very High Very High Very High
corticosteroid 11 98.76 Very High Very High Very High
Acupuncture 130 97.88 Very High Very High Very High
antagonist 11 96.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hantavirus Infection 86 100.00 Very High Very High Very High
Neuropathy 26 99.96 Very High Very High Very High
Disease 206 99.76 Very High Very High Very High
Demyelinating Disease 66 99.76 Very High Very High Very High
INFLAMMATION 53 99.72 Very High Very High Very High
Neuromyelitis Optica 146 98.80 Very High Very High Very High
Necrosis 11 98.36 Very High Very High Very High
Agammaglobulinemia 24 97.88 Very High Very High Very High
Dengue 40 97.84 Very High Very High Very High
Infection 141 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the role of IgG in mediating chemiluminescence activity, seven sera with high ADRB values were individually depleted of IgG by passage over Protein-G, and the flow-through was concentrated to the original volume (IgG depleted serum).
Negative_regulation (depleted) of IgG
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0.07
Dependence of chemiluminescence activity on IgG and complement
Negative_regulation (Dependence) of IgG associated with addiction
2) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0.05
0.6), and (iii) sera depleted of IgG gave negligible activity (lane 3).
Negative_regulation (depleted) of IgG
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0.08
To display total protein content in the CSF, high-abundance proteins, such as IgG and albumin, were not depleted.
Neg (not) Negative_regulation (depleted) of IgG
4) Confidence 0.26 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2730746 Disease Relevance 0.61 Pain Relevance 0.26
The decrease of total IgG for the whole group was just on the brink of statistical significance (P = .05).
Negative_regulation (decrease) of IgG
5) Confidence 0.25 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC3004381 Disease Relevance 0 Pain Relevance 0.04
Corticosteroid therapy resulted in improvement of the clinical findings and lowered his serum IgG4 levels.
Negative_regulation (lowered) of IgG4 associated with corticosteroid
6) Confidence 0.14 Published 2008 Journal Pathol. Int. Section Abstract Doc Link 18577110 Disease Relevance 2.16 Pain Relevance 0.89
Direct immunofluorescence revealed the deposition of IgG at the cell surface of the keratinocytes and C3 at the basement membrane zone.
Negative_regulation (deposition) of IgG in basement membrane
7) Confidence 0.14 Published 1995 Journal Dermatology (Basel) Section Abstract Doc Link 8589481 Disease Relevance 0.96 Pain Relevance 0.08
Total levels of immunoglobulins were normal (except for a small decrease in IgG3), as were C2 and C4 (Table 1).
Neg (except) Negative_regulation (decrease) of IgG3
8) Confidence 0.13 Published 2010 Journal Clin Mol Allergy Section Body Doc Link PMC2856528 Disease Relevance 0.98 Pain Relevance 0
Immunofluorescence revealed predominantly mesangial deposits of IgA and IgG but no IgM nor complement.
Negative_regulation (deposits) of IgG
9) Confidence 0.12 Published 1978 Journal Am. J. Med. Sci. Section Abstract Doc Link 153712 Disease Relevance 0.79 Pain Relevance 0.09
The prospective, longitudinal European Vivaglobin® trial evaluated 60 patients with a variety of PIDD, including IgG subclass deficiency, although the majority carried diagnoses of CVID or XLA.
Negative_regulation (deficiency) of IgG associated with agammaglobulinemia and disease
10) Confidence 0.11 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.98 Pain Relevance 0.09
With the addition of sugars, and subsequently amino acids as stabilizers to prevent aggregation of IgG molecules, the systemic side effects associated with IVIg have been markedly reduced in subsequent generations of IVIg products.
Negative_regulation (aggregation) of IgG
11) Confidence 0.11 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.50 Pain Relevance 0
The serum immunoelectrophoretic pattern showed a virtual absence of IgA and IgM and a very decreased level of IgG.
Negative_regulation (decreased) of IgG
12) Confidence 0.11 Published 1976 Journal Endoscopy Section Abstract Doc Link 1026394 Disease Relevance 0.42 Pain Relevance 0.09
The serum immunoelectrophoretic pattern showed a virtual absence of IgA and IgM and a very decreased level of IgG.
Negative_regulation (level) of IgG
13) Confidence 0.11 Published 1976 Journal Endoscopy Section Abstract Doc Link 1026394 Disease Relevance 0.42 Pain Relevance 0.09
Plasma IgG levels decreased with increasing TCDD plasma concentration (r = -0.35, p = 0.0002).
Negative_regulation (decreased) of IgG in plasma
14) Confidence 0.09 Published 2002 Journal Environ Health Perspect Section Abstract Doc Link PMC1241102 Disease Relevance 0.34 Pain Relevance 0.09
Lambda light chains were the sole contributors to a selective increase in IgD, with a concomitant reduction of IgA, IgG, and IgM.
Negative_regulation (reduction) of IgG
15) Confidence 0.09 Published 1981 Journal J. Neurol. Section Abstract Doc Link 6169807 Disease Relevance 0.99 Pain Relevance 0.15
The CFA effectively removed 93% of CG, without significant removal of IgG, IgM, IgA, albumin, and fibrinogen.
Negative_regulation (removal) of IgG
16) Confidence 0.04 Published 1999 Journal ASAIO J. Section Abstract Doc Link 10360729 Disease Relevance 1.28 Pain Relevance 0.07
Immunofluorescence studies revealed intensive deposition of IgG, IgA, C3, C1q, Fibrinogen, and kappa light chain with granular pattern in the capillary and mesangial area.
Negative_regulation (deposition) of IgG in capillary
17) Confidence 0.04 Published 2009 Journal Clin. Exp. Nephrol. Section Abstract Doc Link 19367362 Disease Relevance 0.77 Pain Relevance 0.27
Probably the most important difference was an early IgG response to CHIKV, compared with a clear delay of IgG (appearing after IgM) in most acute cases of primary dengue virus infection.
Spec (clear) Negative_regulation (delay) of IgG associated with dengue and infection
18) Confidence 0.04 Published 2008 Journal Emerging Infectious Diseases Section Body Doc Link PMC2570846 Disease Relevance 0.88 Pain Relevance 0
Moreover, the suppression of IgG-ISC formation was reversed by mu-, delta-, and kappa-receptor class-selective antagonists, [D'Tic]cTAP, ICI 174,864, and nor-BNI, respectively.
Negative_regulation (suppression) of IgG associated with tics and antagonist
19) Confidence 0.03 Published 1996 Journal J. Neuroimmunol. Section Abstract Doc Link 8642060 Disease Relevance 0.18 Pain Relevance 0.58
Naloxone blocked the inhibitory effect of M6G, M3G, and morphine.
Negative_regulation (effect) of M3G associated with narcan and morphine
20) Confidence 0.03 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10686401 Disease Relevance 0 Pain Relevance 1.02

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