INT112704

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Context Info
Confidence 0.67
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 21.49
Pain Relevance 4.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
chondrocytes 3
carotid body 3
RVLM 1
brain 1
temporomandibular joint 1
Hif1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 18 99.40 Very High Very High Very High
Osteoarthritis 12 98.94 Very High Very High Very High
Rostral ventrolateral medulla 9 97.80 Very High Very High Very High
ischemia 427 97.52 Very High Very High Very High
depression 24 96.80 Very High Very High Very High
tolerance 639 84.44 Quite High
Neurotransmitter 21 80.84 Quite High
Catecholamine 9 80.32 Quite High
Calcium channel 16 76.96 Quite High
anesthesia 48 76.36 Quite High
Disease Link Frequency Relevance Heat
Hypoxia 1670 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 18 99.40 Very High Very High Very High
Death 28 99.18 Very High Very High Very High
Osteoarthritis 12 98.94 Very High Very High Very High
Poisoning 2 98.78 Very High Very High Very High
Adhesions 9 98.66 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 14 98.16 Very High Very High Very High
Repression 6 97.96 Very High Very High Very High
Cv Unclassified Under Development 377 97.52 Very High Very High Very High
Cardiovascular Disorder Under Development 3 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we demonstrate for the first time that hypoxia-inducible factor-1alpha (Hif-1alpha) is activated in mature chondrocytes of temporomandibular joint-osteoarthritis (TMJ-OA) model rat by mechanical overload, and that activated Hif-1 in chondrocytes can induce osteoclastogenesis via repression of osteoprotegerin (Opg) expression.
Positive_regulation (activated) of Hif-1 in chondrocytes associated with snapping jaw, hypoxia, repression and osteoarthritis
1) Confidence 0.67 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.78 Pain Relevance 0.36
Inductions of Hif-1-target genes showed a similar expression pattern.
Positive_regulation (Inductions) of Hif-1-target
2) Confidence 0.67 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.67 Pain Relevance 0.28
Here we demonstrate for the first time that hypoxia-inducible factor-1alpha (Hif-1alpha) is activated in mature chondrocytes of temporomandibular joint-osteoarthritis (TMJ-OA) model rat by mechanical overload, and that activated Hif-1 in chondrocytes can induce osteoclastogenesis via repression of osteoprotegerin (Opg) expression.
Positive_regulation (activated) of hypoxia-inducible factor-1alpha in chondrocytes associated with snapping jaw, hypoxia, repression and osteoarthritis
3) Confidence 0.67 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.73 Pain Relevance 0.37
Here we demonstrate for the first time that hypoxia-inducible factor-1alpha (Hif-1alpha) is activated in mature chondrocytes of temporomandibular joint-osteoarthritis (TMJ-OA) model rat by mechanical overload, and that activated Hif-1 in chondrocytes can induce osteoclastogenesis via repression of osteoprotegerin (Opg) expression.
Positive_regulation (activated) of Hif-1alpha in chondrocytes associated with snapping jaw, hypoxia, repression and osteoarthritis
4) Confidence 0.67 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.73 Pain Relevance 0.37
Activation of the hypoxia-inducible factor-1 in overloaded temporomandibular joint, and induction of osteoclastogenesis.
Positive_regulation (Activation) of hypoxia-inducible factor-1 in temporomandibular joint associated with snapping jaw and hypoxia
5) Confidence 0.67 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 20171183 Disease Relevance 0.78 Pain Relevance 0.36
We conclude that the repertoire of cellular events in RVLM during the prolife phase in our Mev intoxication of brain stem death triggered by hypoxia entails sequential activation of HIF-1, HO-1, and HSP70, leading to neuroprotection by amelioration of cardiovascular depression.
Positive_regulation (activation) of HIF-1 in RVLM associated with rostral ventrolateral medulla, depression, hypoxia, cardiovascular disorder under development, death and poisoning
6) Confidence 0.55 Published 2009 Journal Shock Section Abstract Doc Link 19333137 Disease Relevance 1.07 Pain Relevance 0.41
The expression of a few retinal mRNAs known to be induced by hypoxia, including HIF-1?
Positive_regulation (induced) of HIF-1 associated with hypoxia
7) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.82 Pain Relevance 0
We found a substantial increase in HIF-1 protein during hypoxia, but this does not mean that HIF-1 alone regulated gene expression.
Positive_regulation (increase) of HIF-1 associated with hypoxia
8) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.02 Pain Relevance 0.05
CoCl2 is known to increase HIF-1?
Positive_regulation (increase) of HIF-1
9) Confidence 0.50 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.10 Pain Relevance 0
When ATDC5 cells induced differentiation by insulin were cultured under hypoxia, Hif-1alpha induction was observed in mature stage, but not in immature stage.
Positive_regulation (induction) of Hif-1alpha associated with hypoxia
10) Confidence 0.45 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.69 Pain Relevance 0.29
Results lend support to the idea that HIF-1 stabilization could play a role in the chemotransduction during acute hypoxia.
Positive_regulation (stabilization) of HIF-1 associated with hypoxia
11) Confidence 0.45 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.84 Pain Relevance 0
level and HIF-1 activation in the carotid body.
Positive_regulation (activation) of HIF-1 in carotid body
12) Confidence 0.45 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.76 Pain Relevance 0.08
The observations that under normoxic conditions CPX and DMOG increased the endogenous NO level close to the level induced by acute hypoxia, indicate that HIF-1 activation may be involved in the endogenous NO release during acute hypoxia.
Positive_regulation (activation) of HIF-1 associated with hypoxia
13) Confidence 0.45 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.86 Pain Relevance 0
It was hypothesized that hypoxic chemotranduction with stabilization of HIF-1 and activation of P2X/P2Y purinoceptors stimulate the endogenous NO production in the rat carotid body.
Positive_regulation (stabilization) of HIF-1 in carotid body associated with hypoxia
14) Confidence 0.45 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.49 Pain Relevance 0
In addition, oxoglutarate analogue suppresses PAH activity and increases endogenous HIF-1?
Positive_regulation (increases) of HIF-1
15) Confidence 0.45 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.34 Pain Relevance 0.11
Increased Endogenous Nitric Oxide Release by Iron Chelation and Purinergic Activation in the Rat Carotid Body

We examined the hypothesis that hypoxic chemotransduction with stabilization of HIF-1 and activation of purinoceptors stimulate the endogenous NO production in the rat carotid body.

Spec (examined) Positive_regulation (stabilization) of HIF-1 in carotid body associated with hypoxia
16) Confidence 0.45 Published 2007 Journal The Open Biochemistry Journal Section Title Doc Link PMC2570544 Disease Relevance 0.39 Pain Relevance 0
Depletion of cofactors required for the PAH activity, physiologically by hypoxia or pharmacologically by intracellular iron chelation, increases the HIF-1?
Positive_regulation (increases) of HIF-1 associated with hypoxia
17) Confidence 0.45 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.37 Pain Relevance 0.10
Animals used for measurement of HIF-1?
Positive_regulation (measurement) of HIF-1
18) Confidence 0.36 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.01 Pain Relevance 0.08
HIF-1 activation has been observed in oxygen-induced ischemic retinopathy [17] and in hypoxia [16].
Positive_regulation (activation) of HIF-1 associated with hypoxia and ocular toxicity (including many sub-types)
19) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.37 Pain Relevance 0
Another important molecule, the transcription factor hypoxia inducible factor-1 (HIF-1), is well established as a key molecular signal linking oxygen level to gene expression in many tissues.
Positive_regulation (inducible) of HIF-1 associated with hypoxia
20) Confidence 0.33 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.52 Pain Relevance 0

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