INT112706

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Context Info
Confidence 0.08
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
cardiac myocytes 2
Hif1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 6 50.00 Quite Low
Morphine 6 50.00 Quite Low
analgesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 6 50.00 Quite Low
Hypoxia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using a rat coronary ligation model, we show that morphine treatment: (1) decreases myocardial VEGF protein expression (immunohistochemistry); (2) decreases HIF-1alpha protein expression (immunoblot); and (3) decreases phospho-Erk-1,2 and phospho-Akt expression.
Negative_regulation (decreases) of Gene_expression (expression) of HIF-1alpha
1) Confidence 0.08 Published 2003 Journal Surgery Section Body Doc Link 12947338 Disease Relevance 0 Pain Relevance 0
RESULTS: Using rat cardiac myocytes in vitro, we show that morphine: (1) decreases hypoxia-induced VEGF(121) and VEGF(165) mRNA expression and VEGF protein concentration through an opioid receptor mechanism; (2) decreases HIF-1alpha protein expression (immunoblot) and nuclear protein binding to the VEGF HIF-1alpha DNA response element (EMSA); and (3) inhibits phospho-Erk-1,2 MAP kinase (immunoblot) and phospho-Akt kinase activity (immunoblot).
Negative_regulation (decreases) of Gene_expression (expression) of HIF-1alpha in cardiac myocytes
2) Confidence 0.08 Published 2003 Journal Surgery Section Body Doc Link 12947338 Disease Relevance 0 Pain Relevance 0

General Comments

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