INT112707

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Context Info
Confidence 0.59
First Reported 2003
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 89
Total Number 94
Disease Relevance 28.85
Pain Relevance 27.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Akt1) transport (Akt1) aging (Akt1)
enzyme binding (Akt1) carbohydrate metabolic process (Akt1) cytoplasm (Akt1)
Anatomy Link Frequency
spinal cord 8
hearts 4
muscle 3
neurite 3
neurons 3
Akt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 35 100.00 Very High Very High Very High
Nucleus accumbens 8 100.00 Very High Very High Very High
antagonist 131 99.98 Very High Very High Very High
tetrodotoxin 1 99.98 Very High Very High Very High
Sciatic nerve 2 99.60 Very High Very High Very High
agonist 250 99.58 Very High Very High Very High
Inflammatory marker 2 99.30 Very High Very High Very High
Paracetamol 360 99.24 Very High Very High Very High
qutenza 138 99.20 Very High Very High Very High
ischemia 212 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 277 100.00 Very High Very High Very High
Thymoma 1 100.00 Very High Very High Very High
Aging 236 99.78 Very High Very High Very High
Injury 229 99.76 Very High Very High Very High
Death 76 99.68 Very High Very High Very High
Diabetes Mellitus 429 99.44 Very High Very High Very High
Myocardial Infarction 124 99.28 Very High Very High Very High
Hyperplasia 12 99.18 Very High Very High Very High
Cv Unclassified Under Development 200 99.16 Very High Very High Very High
INFLAMMATION 122 99.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistent with this, directional mitochondrial movement was almost completely blocked by a specific Akt inhibitor.
Negative_regulation (inhibitor) of Akt
1) Confidence 0.59 Published 2007 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 17904380 Disease Relevance 0 Pain Relevance 0.26
Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.
Negative_regulation (inhibitors) of Akt in spinal cord associated with central sensitization, qutenza, hypersensitivity and spinal cord
2) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.47 Pain Relevance 0.80
Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.
Negative_regulation (inhibitors) of Akt in spinal cord associated with central sensitization, qutenza, hypersensitivity and spinal cord
3) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.47 Pain Relevance 0.79
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitors) of Akt associated with qutenza and hypersensitivity
4) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.48 Pain Relevance 0.88
Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.
Negative_regulation (inhibitors) of Akt in spinal cord associated with central sensitization, qutenza, hypersensitivity and spinal cord
5) Confidence 0.58 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.46 Pain Relevance 0.74
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitors) of PKB associated with qutenza and hypersensitivity
6) Confidence 0.57 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.48 Pain Relevance 0.88
Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.
Negative_regulation (inhibitors) of PKB in spinal cord associated with central sensitization, qutenza, hypersensitivity and spinal cord
7) Confidence 0.57 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.46 Pain Relevance 0.74
The PKB/Akt inhibitor, Akt inhibitor IV, has the same effect.
Negative_regulation (inhibitor) of Akt
8) Confidence 0.57 Published 2007 Journal Neuroscience Section Abstract Doc Link 17084039 Disease Relevance 0.33 Pain Relevance 0.80
The PKB/Akt inhibitor, Akt inhibitor IV, has the same effect.
Negative_regulation (inhibitor) of Akt
9) Confidence 0.57 Published 2007 Journal Neuroscience Section Abstract Doc Link 17084039 Disease Relevance 0.33 Pain Relevance 0.80
This finding demonstrates that Akt kinase activity is decreased with aging (Figure 4A).
Negative_regulation (decreased) of Akt kinase associated with aging
10) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.22 Pain Relevance 0.07
Our results show that aging skeletal muscle exhibits impaired Akt kinase activity and that acetaminophen-induced improvements in Akt signaling are associated with increases in myocyte size and the expression of myosin and actin, along with decreases in muscle apoptosis.
Negative_regulation (impaired) of Akt kinase in muscle associated with paracetamol, aging and apoptosis
11) Confidence 0.56 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 1.15 Pain Relevance 0.46
In contrast, in vitro inhibition of either PI3K or Akt causes a decrease in DA uptake capacity and a redistribution of DAT away from the plasma membrane [11,13].
Negative_regulation (inhibition) of Akt in plasma associated with dopamine
12) Confidence 0.48 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.06 Pain Relevance 0.35
In three independent experiments, STZ treatment in rats led to a 44 ± 16% decrease in Akt activity measured from striatal synaptosomes (Figure 1B), suggesting that the STZ treatment significantly downregulates basal PI3K signaling in striatum.
Negative_regulation (decrease) of Akt in striatum
13) Confidence 0.48 Published 2007 Journal PLoS Biology Section Body Doc Link PMC2020502 Disease Relevance 0.08 Pain Relevance 0.10
The down-regulation of nerve growth factor (NGF) mRNA and protein expression in the cortex and thalamus at defined time points between 1 and 24h after the propofol treatment, as well as a decrease of phosphorylated Akt were observed.
Negative_regulation (decrease) of Akt in nerve associated with nerve growth factor and thalamus
14) Confidence 0.46 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19150648 Disease Relevance 0.53 Pain Relevance 0.30
In this study, we used viral-mediated gene transfer in rat to show that chronic morphine-induced downregulation of the insulin receptor substrate 2 (IRS2)-thymoma viral proto-oncogene (Akt) signaling pathway in the VTA mediates the decrease in dopamine cell size seen after morphine exposure and that this downregulation diminishes morphine reward, as measured by conditioned place preference.
Negative_regulation (downregulation) of Akt associated with ventral tegmentum, dopamine, thymoma and morphine
15) Confidence 0.45 Published 2007 Journal Nat. Neurosci. Section Abstract Doc Link 17143271 Disease Relevance 0.10 Pain Relevance 1.21
Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.
Negative_regulation (inhibitor) of Akt in spinal cord associated with central sensitization, qutenza, hypersensitivity and spinal cord
16) Confidence 0.43 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.47 Pain Relevance 0.80
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitor) of Akt associated with qutenza and hypersensitivity
17) Confidence 0.43 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.48 Pain Relevance 0.88
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitors) of Akt associated with qutenza and hypersensitivity
18) Confidence 0.43 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.48 Pain Relevance 0.87
Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.
Negative_regulation (inhibitor) of Akt associated with qutenza and hypersensitivity
19) Confidence 0.43 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.47 Pain Relevance 0.87
Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.
Negative_regulation (inhibitor) of Akt in spinal cord associated with central sensitization, qutenza, hypersensitivity and spinal cord
20) Confidence 0.43 Published 2006 Journal Pain Section Abstract Doc Link 16360265 Disease Relevance 0.47 Pain Relevance 0.79

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