INT112708

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.70
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
neurite 1
Hif1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 3 98.96 Very High Very High Very High
ischemia 8 95.28 Very High Very High Very High
analgesia 1 94.24 High High
antagonist 8 91.68 High High
Neurotransmitter 6 77.60 Quite High
Calcium channel 3 73.72 Quite High
Dopamine 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 259 100.00 Very High Very High Very High
Coronary Artery Disease 3 95.28 Very High Very High Very High
Injury 2 68.20 Quite High
Apoptosis 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 4 5.00 Very Low Very Low Very Low
Cv General 4 Under Development 3 5.00 Very Low Very Low Very Low
Nervous System Injury 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Pheochromocytoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of blockade of purinoceptors with suramin, or blockade of HIF-1?
Negative_regulation (blockade) of HIF-1
1) Confidence 0.38 Published 2007 Journal The Open Biochemistry Journal Section Abstract Doc Link PMC2570544 Disease Relevance 0.29 Pain Relevance 0
In conclusion, iron chelation, which could suppress the PAH activity for HIF-1?
Negative_regulation (suppress) of HIF-1
2) Confidence 0.38 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.76 Pain Relevance 0.08
The major observations of this study are that: (1) iron chelation, which could block HIF-1?
Negative_regulation (block) of HIF-1
3) Confidence 0.28 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.64 Pain Relevance 0
We hypothesize that morphine inhibits myocardial VEGF expression by inhibiting hypoxia-induced factor 1alpha (HIF-1alpha) and the signal transduction mechanisms involving Erk-1,2 MAP kinase (p42/p44), and PI3 kinase activity (phospho-Akt).
Negative_regulation (inhibiting) of HIF-1alpha associated with hypoxia and morphine
4) Confidence 0.08 Published 2003 Journal Surgery Section Abstract Doc Link 12947338 Disease Relevance 0.36 Pain Relevance 0.49
In the present study, we utilized a common hypoxia mimetic (CoCl2) and an inhibitor of HIF-1?
Negative_regulation (inhibitor) of HIF-1 associated with hypoxia
5) Confidence 0.04 Published 2010 Journal J Mol Neurosci Section Body Doc Link PMC2825316 Disease Relevance 0.48 Pain Relevance 0.07
We confirmed neurite extension was mediated through oxygen-responsive mechanisms using small molecules that promote or inhibit HIF-1?
Negative_regulation (inhibit) of HIF-1 in neurite
6) Confidence 0.03 Published 2010 Journal J Mol Neurosci Section Abstract Doc Link PMC2825316 Disease Relevance 0.17 Pain Relevance 0

General Comments

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