INT112709

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 4.15
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) mitochondrion (Mapk3) Golgi apparatus (Mapk3)
protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3)
Mapk3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 16 97.28 Very High Very High Very High
Hippocampus 25 79.28 Quite High
Pain 60 73.84 Quite High
Spinal cord 35 66.00 Quite High
ischemia 4 63.20 Quite High
Lasting pain 17 59.96 Quite High
painful pain 4 53.84 Quite High
Morphine 3 50.00 Quite Low
Dorsal horn 8 46.72 Quite Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 96 98.84 Very High Very High Very High
Diabetes Mellitus 72 98.48 Very High Very High Very High
Cancer 173 96.80 Very High Very High Very High
Targeted Disruption 2 94.84 High High
Injury 2 89.16 High High
Apoptosis 22 84.88 Quite High
Neuroblastoma 4 80.76 Quite High
Pain 82 73.84 Quite High
Breast Cancer 4 71.92 Quite High
Metastasis 5 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to examine the spatial and temporal patterns of ERK1/2 phosphorylation and expression, all three groups of rats were anesthetized with intraperitoneal injection of sodium pentobarbital (50 mg/kg, i.p.) and decapitated at various time points (5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 6 h, 24 h, 48 h) after the injection.
Spec (examine) Negative_regulation (patterns) of Gene_expression (expression) of ERK1
1) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1949833 Disease Relevance 0.30 Pain Relevance 0.37
This effect is associated with downregulation of retinal VEGF and phospho-p42/p44 MAP kinase expression, and a reduction in the retinal occludin loss induced by diabetes.
Negative_regulation (downregulation) of Gene_expression (expression) of p44 associated with diabetes mellitus
2) Confidence 0.22 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.90 Pain Relevance 0.03
Expression of ERK1/2 was also reduced by 27 ± 7.7% and 31 ± 8.7% respectively. mRNA expression of matrix metalloproteinase-2 (MMP2) was reduced by 35 ± 6.8% and zymography showed MMP2 proteolytic activity was reduced by 32 ± 8.5%.
Negative_regulation (reduced) of Gene_expression (Expression) of ERK1 associated with metalloproteinase
3) Confidence 0.09 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2661078 Disease Relevance 0.63 Pain Relevance 0.05
The decrease in ERK1 and ERK2 expression may be involved in the decrease in VEGF and Flt1 expression in the GLA treated tumours.
Negative_regulation (decrease) of Gene_expression (expression) of ERK1 associated with cancer
4) Confidence 0.09 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.65 Pain Relevance 0
The presence of GLA caused inhibition of mRNA expression of VEGF, Flt1, ERK1/2 and MMP2 but not Flk1.
Negative_regulation (inhibition) of Gene_expression (expression) of ERK1
5) Confidence 0.09 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.80 Pain Relevance 0
ERK1 and ERK2 mRNA and protein expression was significantly decreased.
Negative_regulation (decreased) of Gene_expression (expression) of ERK1
6) Confidence 0.09 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.88 Pain Relevance 0
Using a rat coronary ligation model, we show that morphine treatment: (1) decreases myocardial VEGF protein expression (immunohistochemistry); (2) decreases HIF-1alpha protein expression (immunoblot); and (3) decreases phospho-Erk-1,2 and phospho-Akt expression.
Negative_regulation (decreases) of Gene_expression (expression) of Erk-1
7) Confidence 0.08 Published 2003 Journal Surgery Section Body Doc Link 12947338 Disease Relevance 0 Pain Relevance 0

General Comments

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