INT112713

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Context Info
Confidence 0.75
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 20.48
Pain Relevance 5.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
retinas 3
hypertrophic chondrocytes 2
cardiac myocytes 1
brain 1
Hif1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
calcitonin gene related peptide 6 100.00 Very High Very High Very High
opioid receptor 30 99.98 Very High Very High Very High
ischemia 99 99.28 Very High Very High Very High
Glutamate receptor 36 97.12 Very High Very High Very High
Enkephalin 3 96.40 Very High Very High Very High
adenocard 31 93.16 High High
potassium channel 30 91.04 High High
Neurotransmitter 6 90.68 High High
antagonist 12 89.36 High High
Osteoarthritis 10 88.72 High High
Disease Link Frequency Relevance Heat
Hypoxia 1530 100.00 Very High Very High Very High
Cv Unclassified Under Development 74 99.28 Very High Very High Very High
Apoptosis 57 97.56 Very High Very High Very High
Ocular Hypertension 18 97.24 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 18 95.80 Very High Very High Very High
Stress 51 94.64 High High
Repression 5 93.88 High High
Adhesions 9 93.44 High High
Increased Venous Pressure Under Development 10 90.96 High High
Injury 131 90.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hif-1alpha expression was observed specifically in mature and hypertrophic chondrocytes, and Hif-1alpha-positivity, level of Vegf expression, and tartrate-resistant acid phosphatase (TRAP)-positive cell numbers all increased in the same manner.
Gene_expression (expression) of Hif-1alpha in hypertrophic chondrocytes
1) Confidence 0.75 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.74 Pain Relevance 0.33
When ATDC5 cells induced differentiation by insulin were cultured under hypoxia, Hif-1alpha induction was observed in mature stage, but not in immature stage.
Gene_expression (induction) of Hif-1alpha associated with hypoxia
2) Confidence 0.65 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.69 Pain Relevance 0.29
Inductions of Hif-1-target genes showed a similar expression pattern.
Gene_expression (expression) of Hif-1-target
3) Confidence 0.65 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.66 Pain Relevance 0.28
In addition, expression of Opg decreased in hypoxia, and Hif-1alpha played a role, in part, in its regulation.
Gene_expression (expression) of Hif-1alpha associated with hypoxia
4) Confidence 0.58 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.74 Pain Relevance 0.27
Hif-1alpha expression was observed specifically in mature and hypertrophic chondrocytes, and Hif-1alpha-positivity, level of Vegf expression, and tartrate-resistant acid phosphatase (TRAP)-positive cell numbers all increased in the same manner.
Gene_expression (expression) of Hif-1alpha-positivity in hypertrophic chondrocytes
5) Confidence 0.58 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 20171183 Disease Relevance 0.73 Pain Relevance 0.32
Kaur et al. [68] examined selected gene expression patterns in rat retinas from 3 to 14 days after hypoxia. mRNAs and protein expression for HIF-1?
Gene_expression (expression) of HIF-1 in retinas associated with hypoxia
6) Confidence 0.55 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.94 Pain Relevance 0.12
In addition, temporal [17] and spatial [16,17] correlations between increased levels of HIF-1?
Gene_expression (levels) of HIF-1
7) Confidence 0.55 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.13 Pain Relevance 0
HPC markedly increased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and DOR, but intravitreal administration of HIF-1alpha-specific small interfering RNA abrogated the up-regulation of DOR.
Gene_expression (expression) of hypoxia-inducible factor-1alpha associated with hypoxia and opioid receptor
8) Confidence 0.52 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19054276 Disease Relevance 1.09 Pain Relevance 0.54
HPC markedly increased the expression of hypoxia-inducible factor-1alpha (HIF-1alpha) and DOR, but intravitreal administration of HIF-1alpha-specific small interfering RNA abrogated the up-regulation of DOR.
Gene_expression (expression) of HIF-1alpha associated with hypoxia and opioid receptor
9) Confidence 0.52 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19054276 Disease Relevance 1.09 Pain Relevance 0.54
The expression of cNOS, CGRP, HIF-1alpha, VEGF and ghrelin was evaluated by reverse transcription polymerase chain reaction or Western blot.
Gene_expression (expression) of HIF-1alpha associated with calcitonin gene related peptide
10) Confidence 0.51 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16581065 Disease Relevance 1.08 Pain Relevance 0.59
Kaur et al. [68] examined selected gene expression patterns in rat retinas from 3 to 14 days after hypoxia. mRNAs and protein expression for HIF-1?
Spec (examined) Gene_expression (expression) of HIF-1 in retinas associated with hypoxia
11) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.97 Pain Relevance 0.12
We found a substantial increase in HIF-1 protein during hypoxia, but this does not mean that HIF-1 alone regulated gene expression.
Gene_expression (expression) of HIF-1 associated with hypoxia
12) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.05 Pain Relevance 0.04
Most of the genes that were upregulated during hypoxia in our study are not known to be controlled by HIF-1.
Gene_expression (controlled) of HIF-1 associated with hypoxia
13) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.02 Pain Relevance 0.04
, the regulatory subunit of HIF-1, and increased VEGF expression have been shown, indicating that HIF-1 may control the expression of VEGF in the retina under hypoxic conditions.
Gene_expression (expression) of HIF-1 in retina associated with hypoxia
14) Confidence 0.48 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 1.07 Pain Relevance 0
This suggested that DOR functions downstream of HIF-1alpha.
Gene_expression (functions) of HIF-1alpha associated with opioid receptor
15) Confidence 0.45 Published 2009 Journal J. Neurochem. Section Abstract Doc Link 19054276 Disease Relevance 1.02 Pain Relevance 0.57
The HIF-1?
Gene_expression (The) of HIF-1
16) Confidence 0.43 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.39 Pain Relevance 0.07
The protein level of HIF-1?
Gene_expression (level) of HIF-1
17) Confidence 0.43 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.41 Pain Relevance 0.05
In addition, it has been reported that NO can modulate the level of HIF-1?
Gene_expression (level) of HIF-1
18) Confidence 0.43 Published 2007 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570544 Disease Relevance 0.76 Pain Relevance 0.09
Levels of HIF-1?
Gene_expression (Levels) of HIF-1
19) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.19 Pain Relevance 0
Many of the genes known to be directly transactivated by the overexpression of the transcription co-factor HIF-1?
Gene_expression (overexpression) of HIF-1
20) Confidence 0.43 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2635851 Disease Relevance 0.61 Pain Relevance 0.04

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