INT112728

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 4.80
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (COQ7) nucleus (COQ7)
Anatomy Link Frequency
liver 2
pancreas 1
COQ7 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 4 95.36 Very High Very High Very High
Migraine 4 91.04 High High
Inflammation 4 90.56 High High
Bile 8 89.84 High High
Disease Link Frequency Relevance Heat
Leigh Syndrome 12 98.82 Very High Very High Very High
Epilepsy 4 95.44 Very High Very High Very High
Fibrosis 4 95.36 Very High Very High Very High
Muscle Weakness 4 94.64 High High
Sensorineural Hearing Loss 4 93.52 High High
Ataxia 4 93.28 High High
Frailty 4 91.76 High High
Hyperammonemia 4 91.64 High High
Headache 4 91.04 High High
Tyrosinemia 4 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of CoQ to the liver homogenate restored the activities, suggesting CoQ depletion.
Negative_regulation (depletion) of CoQ in liver
1) Confidence 0.50 Published 2003 Journal Mol. Genet. Metab. Section Abstract Doc Link 12948744 Disease Relevance 1.30 Pain Relevance 0.26
There are very few reports on human CoQ deficiency.
Negative_regulation (deficiency) of CoQ
2) Confidence 0.42 Published 2003 Journal Mol. Genet. Metab. Section Abstract Doc Link 12948744 Disease Relevance 1.11 Pain Relevance 0.14
This may be the first case of Leigh syndrome with liver and pancreas insufficiency, possibly caused by CoQ responsive oxphos deficiency.
Negative_regulation (deficiency) of CoQ in pancreas associated with leigh syndrome
3) Confidence 0.37 Published 2003 Journal Mol. Genet. Metab. Section Abstract Doc Link 12948744 Disease Relevance 1.19 Pain Relevance 0.24
This may be the first case of Leigh syndrome with liver and pancreas insufficiency, possibly caused by CoQ responsive oxphos deficiency.
Negative_regulation (deficiency) of CoQ in liver associated with leigh syndrome
4) Confidence 0.13 Published 2003 Journal Mol. Genet. Metab. Section Abstract Doc Link 12948744 Disease Relevance 1.19 Pain Relevance 0.24

General Comments

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