INT11274

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Context Info
Confidence 0.48
First Reported 1990
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.47
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk)
Anatomy Link Frequency
neurons 2
striatum 2
granule cells 2
Penk (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 12 100.00 Very High Very High Very High
Inflammation 6 99.98 Very High Very High Very High
Spinal cord 3 99.56 Very High Very High Very High
GABAergic 2 98.64 Very High Very High Very High
Opioid 1 95.96 Very High Very High Very High
agonist 2 84.80 Quite High
Dorsal horn 3 81.12 Quite High
gABA 1 78.40 Quite High
Hippocampus 4 75.00 Quite High
GABA receptor 1 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.98 Very High Very High Very High
Convulsion 1 90.08 High High
Epilepsy 1 79.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In particular, the up-regulated PENK gene that is induced by KA in the hippocampal dentate granule cells has proconvulsant properties.
Positive_regulation (induced) of Positive_regulation (induced) of PENK in granule cells
1) Confidence 0.48 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.17 Pain Relevance 0.19
In order to assess changes in enkephalin release and biosynthesis, the levels of the tripeptide Tyr-Gly-Gly (YGG), a characteristic extracellular metabolite of enkephalins, and of the proenkephalin mRNA in mouse striatum were evaluated after a single administration of GABAergic agents.
Positive_regulation (evaluated) of Positive_regulation (levels) of proenkephalin in striatum associated with gabaergic and enkephalin
2) Confidence 0.44 Published 1990 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 2170800 Disease Relevance 0 Pain Relevance 0.55
Our findings indicated that peripheral inflammation induces an increase in preproenkephalin mRNA levels in spinal cord neurons and that most neurons exhibiting preproenkephalin mRNA labeling also co-localized Fos and Fos-related immunoreactivity.
Positive_regulation (induces) of Positive_regulation (increase) of preproenkephalin mRNA in neurons associated with inflammation and spinal cord
3) Confidence 0.16 Published 1992 Journal Neuroscience Section Abstract Doc Link 1545910 Disease Relevance 0.30 Pain Relevance 0.34

General Comments

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