INT11275

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Context Info
Confidence 0.60
First Reported 1992
Last Reported 2011
Negated 5
Speculated 1
Reported most in Abstract
Documents 37
Total Number 38
Disease Relevance 5.79
Pain Relevance 18.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
brain 3
striatum 2
neural 2
spinal 2
cell groups 1
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 20 100.00 Very High Very High Very High
withdrawal 16 100.00 Very High Very High Very High
analgesia 6 100.00 Very High Very High Very High
local anesthetic 2 100.00 Very High Very High Very High
Spinal cord 14 99.98 Very High Very High Very High
medulla 64 99.84 Very High Very High Very High
Intracerebroventricular 13 99.84 Very High Very High Very High
Hippocampus 20 99.80 Very High Very High Very High
agonist 52 99.72 Very High Very High Very High
narcan 8 99.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Porphyria 7 99.38 Very High Very High Very High
Urological Neuroanatomy 5 99.12 Very High Very High Very High
Targeted Disruption 43 95.60 Very High Very High Very High
Pain 11 94.64 High High
Attention Deficit Hyperactivity Disorder 65 94.56 High High
Headache 4 93.28 High High
Stress 16 92.72 High High
Nociception 8 91.12 High High
Opiate Addiction 1 82.48 Quite High
INFLAMMATION 5 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute dizocilpine treatment prior to the naloxone-challenge and repeated treatment with dizocilpine alone had no effect on analgesia, withdrawal manifestations, p-CaMK II levels or c-Fos protein levels.
Neg (no) Regulation (effect) of c-Fos associated with narcan, withdrawal and analgesia
1) Confidence 0.60 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15196794 Disease Relevance 0.22 Pain Relevance 1.55
The endogenous proenkephalin mRNA was induced in parallel with the transgene as demonstrated by in situ hybridization; the immediate-early gene c-fos was also regulated in parallel with the transgene.
Regulation (regulated) of c-fos
2) Confidence 0.60 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 7996174 Disease Relevance 0.80 Pain Relevance 0.72
These data on the effects of local anesthetics on PKC activity and c-Fos in vivo are of relevance for studies aimed at delineating the biochemical basis of spinal and epidural anesthesia.
Regulation (effects) of c-Fos in spinal associated with anesthesia, kinase c, epidural and local anesthetic
3) Confidence 0.60 Published 1996 Journal Anesth. Analg. Section Abstract Doc Link 8780278 Disease Relevance 0 Pain Relevance 1.13
OBJECTIVE: To study the change of c-fos mRNA and protein in hippocampus of morphine addicted mice after injected with ribozyme specially cleaving per1 mRNA.
Regulation (change) of c-fos mRNA in hippocampus associated with hippocampus and morphine
4) Confidence 0.57 Published 2005 Journal Space Med Med Eng (Beijing) Section Abstract Doc Link 15977398 Disease Relevance 0 Pain Relevance 0.26
PENK is regulated by the c-jun amino-terminal kinase (JNK) signaling pathway, the crucial role of which is involved in the regulation of transcription factors, such as Jun and Fos.
Regulation (regulation) of Fos
5) Confidence 0.52 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16300887 Disease Relevance 0.15 Pain Relevance 0.20
Furthermore, the analysis by real-time RT-PCR also revealed a down-regulation of cFos mRNA in the diffuser-treated eyes after 30 min and even after 6+6 h.
Regulation (regulation) of cFos mRNA in eyes
6) Confidence 0.44 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.14 Pain Relevance 0.04
Effect of GLP-1Rc blockade on c-Fos expression pattern during intragastric glucose infusion.
Regulation (Effect) of c-Fos
7) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.35 Pain Relevance 0.04
We then assessed whether activation of the GLP-1Rc was essential for regulation of the neural c-Fos expression pattern observed in response to the activation of enteric glucose sensor.
Regulation (regulation) of c-Fos in neural
8) Confidence 0.44 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.31 Pain Relevance 0.04
In order to investigate the c-fos response within the trigeminal nucleus caudalis (Sp5C) after noxious meningeal stimulation, capsaicin (0.25, 0.5, 1 and 5 nmol) was administered intracisternally in urethane (1 g/kg) and alpha-chloralose (20 mg/kg) anaesthetized male mice.
Spec (investigate) Regulation (response) of c-fos in nucleus associated with qutenza
9) Confidence 0.26 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12110114 Disease Relevance 0 Pain Relevance 0.28
However, in animals that had undergone monocular enucleation, column-like patches of c-Fos and MHCI-HC immunoreactivity were visible throughout layer IV of V1 (Figure 9C and 9D and Additional file 6).
Regulation (immunoreactivity) of c-Fos
10) Confidence 0.26 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
We studied the dopamine (DA) D1 receptor gene and one of its downstream targets, the transcription factor c-Fos.
Regulation (targets) of c-Fos associated with dopamine
11) Confidence 0.26 Published 2002 Journal J. Chem. Neuroanat. Section Abstract Doc Link 12048106 Disease Relevance 0.12 Pain Relevance 0.45
This was accompanied with reduced c-Fos immunoreactivity in the spinal cord dorsal horn in EP3 knockouts.
Regulation (immunoreactivity) of c-Fos in spinal cord dorsal horn associated with dorsal horn and spinal cord
12) Confidence 0.26 Published 2009 Journal Eur J Pain Section Abstract Doc Link 18938093 Disease Relevance 1.18 Pain Relevance 0.96
Our results show that c-fos and junB responses occur in the brain in response to irradiation and that they can be modified by pentobarbital treatment but suggest that there is no direct correlation between the level of mRNA expression and later expression of cytokines or other acute-phase response genes.
Regulation (responses) of c-fos in brain associated with cytokine
13) Confidence 0.26 Published 1997 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9332719 Disease Relevance 0.07 Pain Relevance 0.18
By day 21, as in adult animals, no more c-fos response to D1 agonists was observed, except in the most caudal division of the striatum.
Neg (no) Regulation (response) of c-fos in striatum associated with agonist
14) Confidence 0.26 Published 1995 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 7637573 Disease Relevance 0 Pain Relevance 0.40
In comparison with sham and saline conditions, NGF administration induced significantly stronger Fos immunoreactivity in the mesencephalic periaqueductal grey (PAG), the medullary lateral reticular nucleus (LRN), and superficial layers I and II of cervical spinal dorsal horns C1, C2 and C3.
Regulation (immunoreactivity) of Fos in spinal associated with nerve growth factor, periaqueductal grey and urological neuroanatomy
15) Confidence 0.25 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16426266 Disease Relevance 0.41 Pain Relevance 0.66
Morphine treatment induced both motor activity and Fos immunoreactivity in the NAc, ACg and PrL suggesting that behavioral stimulation is produced by neural activation in these regions.
Regulation (immunoreactivity) of Fos in neural associated with nucleus accumbens, anterior cingulate cortex and morphine
16) Confidence 0.25 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19027733 Disease Relevance 0 Pain Relevance 1.94
Next, morphine was administered on days 1, 3, 5, and 9 and mice demonstrated sensitization to its motor stimulant effects and concomitant induction of Fos immunoreactivity in the NAc shell (NAcS) but not NAc core.
Regulation (immunoreactivity) of Fos in NAcS associated with nucleus accumbens and morphine
17) Confidence 0.25 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14610238 Disease Relevance 0 Pain Relevance 1.83
PBG injections had no significant effects on the number of c-Fos-positive catecholaminergic neurones within the C1/A1, C2/A2, A5, A6 and A7 cell groups.
Neg (no) Regulation (effects) of c-Fos-positive in cell groups associated with porphyria
18) Confidence 0.24 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 16298172 Disease Relevance 0.77 Pain Relevance 0.54
Fos is a transcription factor that is up-regulated in the mid-brain in
   response to stimulation from drugs, or other natural rewarding stimuli such as sexual behavior
   or exercise 123, 150. 
Regulation (regulated) of Fos in brain
19) Confidence 0.23 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0 Pain Relevance 0.37
Thus, while Fos and BDNF are two examples of downstream transcription factors regulated by
   dopamine signaling, the dopamine system potentially affects a large number of downstream genes
   and signaling pathways that may ultimately be important in the understanding of the genetic
   mechanisms involved in regulation of physical activity levels in animals and humans. 
Regulation (regulated) of Fos associated with dopamine
20) Confidence 0.23 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 0 Pain Relevance 0.53

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