INT112758

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.60
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ppard) lipid binding (Ppard) cell proliferation (Ppard)
nucleus (Ppard) DNA binding (Ppard) lipid metabolic process (Ppard)
Anatomy Link Frequency
bowel 1
Ppard (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 16 99.52 Very High Very High Very High
cINOD 24 99.12 Very High Very High Very High
COX2 15 98.46 Very High Very High Very High
Neuropathic pain 17 96.96 Very High Very High Very High
Inflammation 19 95.92 Very High Very High Very High
COX-2 inhibitor 3 95.60 Very High Very High Very High
Pain 41 80.52 Quite High
interstitial cystitis 1 76.08 Quite High
Pain score 3 75.00 Quite High
cannabis 46 71.92 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 17 97.52 Very High Very High Very High
Neuropathic Pain 23 96.96 Very High Very High Very High
Inflammatory Bowel Disease 2 95.92 Very High Very High Very High
INFLAMMATION 25 94.04 High High
Polyps 1 93.92 High High
Colon Cancer 7 92.52 High High
Cancer 8 88.72 High High
Pain 58 80.52 Quite High
Interstitial Cystitis 1 76.08 Quite High
Sleep Disorders 5 69.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was further suggested that inhibition of COX2-derived prostaglandins by NSAIDs could reduce levels of putative endogenous ligands of peroxisome proliferator-activated receptor-beta (PPARbeta), and these ligands could potentiate tumorigenesis.
peroxisome proliferator-activated receptor-beta Binding (ligands) of associated with cinod and cox2
1) Confidence 0.37 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16418176 Disease Relevance 0.09 Pain Relevance 0.46
It was further suggested that inhibition of COX2-derived prostaglandins by NSAIDs could reduce levels of putative endogenous ligands of peroxisome proliferator-activated receptor-beta (PPARbeta), and these ligands could potentiate tumorigenesis.
PPARbeta Binding (ligands) of associated with cinod and cox2
2) Confidence 0.37 Published 2006 Journal Carcinogenesis Section Abstract Doc Link 16418176 Disease Relevance 0.09 Pain Relevance 0.46
NSAIDs and COXIBs block PGI(2) production, thereby reducing PPARdelta DNA binding activity and abrogating 14-3-3e upregulation.
PPARdelta Binding (binding) of associated with cinod
3) Confidence 0.32 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.62 Pain Relevance 0.29
PGI2 activates PPARdelta resulting in binding of PPARdelta to specific PPAR response elements (PPRE) of target genes.
PPARdelta Binding (binding) of
4) Confidence 0.25 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.68 Pain Relevance 0.28
NSAIDs and COXIBs block PGI(2) production, thereby reducing PPARdelta DNA binding activity and abrogating 14-3-3e upregulation.
PPARdelta Binding (activity) of associated with cinod
5) Confidence 0.24 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.62 Pain Relevance 0.29
It is hypothesized that 5-ASAs may prevent the enhancing effect of prostaglandins on PPARdelta binding to DNA by its COX inhibitory properties, decreasing proliferation of colorectal mucosal cells in non-inflammatory bowel disease patients with sporadic polyps of the large bowel.
PPARdelta Binding (binding) of in bowel associated with inflammation and polyps
6) Confidence 0.09 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12950415 Disease Relevance 0.82 Pain Relevance 0.41
Part of its analgesic activity may relate to binding to intracellular peroxisome proliferator-activator receptor gamma (Liu et al 2003).
intracellular peroxisome proliferator-activator receptor gamma Binding (binding) of associated with analgesic
7) Confidence 0.03 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2503660 Disease Relevance 0.67 Pain Relevance 0.69

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