INT112759

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Context Info
Confidence 0.39
First Reported 2003
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 2.08
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ppard) lipid binding (Ppard) cell proliferation (Ppard)
nucleus (Ppard) DNA binding (Ppard) lipid metabolic process (Ppard)
Anatomy Link Frequency
bowel 2
Ppard (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 8 99.10 Very High Very High Very High
Inflammation 6 96.04 Very High Very High Very High
COX-2 inhibitor 2 95.60 Very High Very High Very High
aspirin 1 64.44 Quite High
COX2 5 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 11 97.88 Very High Very High Very High
INFLAMMATION 7 96.04 Very High Very High Very High
Inflammatory Bowel Disease 2 95.92 Very High Very High Very High
Polyps 1 93.92 High High
Colon Cancer 5 78.08 Quite High
Cancer 2 74.28 Quite High
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSAIDs and COXIBs block PGI(2) production, thereby reducing PPARdelta DNA binding activity and abrogating 14-3-3e upregulation.
Negative_regulation (reducing) of PPARdelta Binding (binding) of associated with cinod
1) Confidence 0.39 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.62 Pain Relevance 0.29
NSAIDs and COXIBs block PGI(2) production, thereby reducing PPARdelta DNA binding activity and abrogating 14-3-3e upregulation.
Negative_regulation (reducing) of PPARdelta Binding (activity) of associated with cinod
2) Confidence 0.29 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.62 Pain Relevance 0.29
It is hypothesized that 5-ASAs may prevent the enhancing effect of prostaglandins on PPARdelta binding to DNA by its COX inhibitory properties, decreasing proliferation of colorectal mucosal cells in non-inflammatory bowel disease patients with sporadic polyps of the large bowel.
Negative_regulation (prevent) of PPARdelta Binding (binding) of in bowel associated with inflammation and polyps
3) Confidence 0.08 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12950415 Disease Relevance 0.83 Pain Relevance 0.41

General Comments

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