INT112760

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Context Info
Confidence 0.38
First Reported 2003
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.45
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Smpd1) hydrolase activity, acting on glycosyl bonds (Smpd1) lysosome (Smpd1)
Anatomy Link Frequency
lungs 2
Smpd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 8 100.00 Very High Very High Very High
fibrosis 8 99.48 Very High Very High Very High
aspirin 1 93.92 High High
cINOD 2 91.28 High High
cytokine 2 78.64 Quite High
Endep 1 50.08 Quite High
Desipramine 1 47.76 Quite Low
fluoxetine 1 45.36 Quite Low
COX2 1 25.00 Low Low
cOX1 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 7 100.00 Very High Very High Very High
Apoptosis 1 100.00 Very High Very High Very High
Cystic Fibrosis 8 99.48 Very High Very High Very High
Pulmonary Disease 1 87.72 High High
Infection 2 77.44 Quite High
Inflammatory Bowel Disease 2 75.00 Quite High
Colon Cancer 1 75.00 Quite High
Pseudomonas Infection 1 30.24 Quite Low
Polyps 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested whether inhalation of different acid sphingomyelinase inhibitors does reduce Asm activity and ceramide accumulation in lungs of CF mice.
Spec (whether) Negative_regulation (reduce) of Spec (whether) Positive_regulation (accumulation) of Asm in lungs associated with fibrosis
1) Confidence 0.38 Published 2010 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 19635928 Disease Relevance 0.74 Pain Relevance 0.35
The putative chemopreventive actions include the inhibition of inflammatory cascades and/or reactions involved in cell growth and proliferation, such as cyclo-oxygenase (COX-1 and COX-2), which regulate cell proliferation through the formation of prostaglandins; lipoxygenase; nuclear factor kappaB (NFkappaB), responsible for the subsequent expression of pro-inflammatory molecules; MAP kinases and Bcl-2, as well as the activation of apoptotic processes, such as the stimulation of intestinal sphingomyelinase.
Negative_regulation (inhibition) of Positive_regulation (stimulation) of intestinal sphingomyelinase associated with inflammation and apoptosis
2) Confidence 0.00 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12950415 Disease Relevance 0.72 Pain Relevance 0.49

General Comments

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