INT11277

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Context Info
Confidence 0.78
First Reported 1992
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 6.58
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fos) DNA binding (Fos) transcription factor binding (Fos)
Anatomy Link Frequency
neurons 4
finger 2
ganglion cells 2
brain 1
nucleus 1
Fos (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 60 99.84 Very High Very High Very High
imagery 6 99.40 Very High Very High Very High
Dorsal horn neuron 5 99.08 Very High Very High Very High
Spinal cord 15 98.38 Very High Very High Very High
Enkephalin 4 98.06 Very High Very High Very High
allodynia 1 96.76 Very High Very High Very High
Migraine 2 96.60 Very High Very High Very High
depression 1 95.60 Very High Very High Very High
Central grey 2 95.44 Very High Very High Very High
Pain 4 92.32 High High
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 2 100.00 Very High Very High Very High
Ganglion Cysts 95 99.86 Very High Very High Very High
INFLAMMATION 53 99.84 Very High Very High Very High
Convulsion 27 99.68 Very High Very High Very High
Aids-related Complex 50 99.12 Very High Very High Very High
Stress 21 97.96 Very High Very High Very High
Sprains And Strains 53 97.76 Very High Very High Very High
Shock 6 96.88 Very High Very High Very High
Neuropathic Pain 1 96.76 Very High Very High Very High
Headache 2 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colocalization of c-Fos and POMC was determined by merging the individual signals of c-Fos and POMC with Adobe Photoshop 7.0 after the number of c-Fos–and POMC-positive cells was separately counted.
Localization (Colocalization) of c-Fos
1) Confidence 0.78 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0 Pain Relevance 0.05
Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).
Localization (peptidase) of cFos in finger associated with osteogenic sarcomas
2) Confidence 0.73 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0
Colocalization of c-Fos–positive cells with POMC- or NPY-positive cells in the ARC.
Localization (Colocalization) of c-Fos associated with aids-related complex
3) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.32 Pain Relevance 0.03
In a second set of experiments, NPY and c-Fos were colocalized by immunohistochemistry because immunofluorescence was not successful.
Localization (colocalized) of c-Fos
4) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.05 Pain Relevance 0
In the first set of experiments, POMC and c-Fos were colocalized by immunofluorescence.
Localization (colocalized) of c-Fos
5) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.18 Pain Relevance 0
By contrast, c-Fos was found widely expressed in both groups and was localized in neurons in regions associated with response to stress, immunomodulation, and fluid homeostasis, including the periaqueductal gray and periventricular nucleus.
Localization (localized) of c-Fos in periventricular nucleus associated with stress and central grey
6) Confidence 0.73 Published 2004 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15207916 Disease Relevance 0.61 Pain Relevance 0.25
Induction of c-Fos is an early marker of neuronal activity and is a robust marker of seizure activity [25]. c-Fos immunohistochemistry, performed one hour after handling, on brain sections of 5 animals of WT or HDAC4?
Localization (sections) of c-Fos in neuronal associated with convulsion
7) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2720538 Disease Relevance 1.50 Pain Relevance 0.05
B (p65 subunit) and AP-1 (c-Fos) were then measured from 8 ?
Localization (measured) of c-Fos
8) Confidence 0.73 Published 2010 Journal Part Fibre Toxicol Section Body Doc Link PMC2861012 Disease Relevance 0.16 Pain Relevance 0.12
m in the ARC of the hypothalamus were processed for the colocalization of c-Fos, NPY, and POMC.
Localization (colocalization) of c-Fos in hypothalamus associated with aids-related complex
9) Confidence 0.73 Published 2008 Journal Diabetes Section Body Doc Link PMC2551668 Disease Relevance 0.18 Pain Relevance 0
It is to be understood, however, that the Fos localizations are not sufficient unto themselves, but the major function of these studies is to efficiently locate populations of cells in nociceptive pathways so that powerful anatomic and physiologic techniques can be brought to bear efficiently.
Localization (localizations) of Fos associated with nociception
10) Confidence 0.70 Published 2005 Journal Prog. Neurobiol. Section Abstract Doc Link 16356622 Disease Relevance 0.57 Pain Relevance 0.50
Primers for the detection of c-Fos were: forward 5'-CGAAGGGAAAGGAATAAGAT-3', reverse 5'-GCAGACTTCTCATCTTCCAG-3' (marmoset c-Fos, Ensembl transcript number ENSCJAT00000040535).
Localization (detection) of c-Fos
11) Confidence 0.68 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0 Pain Relevance 0
Response of the brain to oligemia: gene expression, c-Fos, and Nrf2 localization.
Localization (localization) of c-Fos in brain
12) Confidence 0.68 Published 2004 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 15207916 Disease Relevance 0.48 Pain Relevance 0.26
PYY(3-36) activated neurons in the midregion of the nucleus of the solitary tract (bregma -7.32 to -7.76 mm) in A-IV(+/+) mice; this was measured by immunohistochemical localization of Fos protein.
Localization (localization) of Fos in nucleus
13) Confidence 0.66 Published 2007 Journal Endocrinology Section Abstract Doc Link 17641001 Disease Relevance 0.14 Pain Relevance 0.40
Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).
Localization (peptidase) of FBJ osteosarcoma oncogene in finger associated with osteogenic sarcomas
14) Confidence 0.64 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0
-galactosidase ganglion cells were Fos-positive (295 Fos+ ?
Localization (were) of Fos in ganglion cells associated with ganglion cysts
15) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.33 Pain Relevance 0.27
-gal), very similar to number of Fos-positive ?
Localization (number) of Fos-positive
16) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.28 Pain Relevance 0.23
-galactosidase ganglion cells were Fos-positive (295 Fos+ ?
Localization (were) of Fos-positive in ganglion cells associated with ganglion cysts
17) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2655650 Disease Relevance 0.33 Pain Relevance 0.27
Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins.
Localization (co-localized) of Fos in neurons associated with inflammation, enkephalin and dorsal horn neuron
18) Confidence 0.25 Published 1992 Journal Neuroscience Section Title Doc Link 1545910 Disease Relevance 0.33 Pain Relevance 0.55
Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins.
Localization (co-localized) of Fos in neurons associated with inflammation, enkephalin and dorsal horn neuron
19) Confidence 0.25 Published 1992 Journal Neuroscience Section Title Doc Link 1545910 Disease Relevance 0.33 Pain Relevance 0.55
Our findings indicated that peripheral inflammation induces an increase in preproenkephalin mRNA levels in spinal cord neurons and that most neurons exhibiting preproenkephalin mRNA labeling also co-localized Fos and Fos-related immunoreactivity.
Localization (localized) of Fos in neurons associated with inflammation and spinal cord
20) Confidence 0.24 Published 1992 Journal Neuroscience Section Abstract Doc Link 1545910 Disease Relevance 0.29 Pain Relevance 0.30

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