INT112779

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Context Info
Confidence 0.50
First Reported 2003
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.63
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc1) Golgi apparatus (Abcc1) ATPase activity (Abcc1)
plasma membrane (Abcc1) nucleus (Abcc1) transmembrane transport (Abcc1)
Abcc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 22 99.56 Very High Very High Very High
Bile 2 95.20 Very High Very High Very High
Potency 1 87.60 High High
Analgesic 1 87.28 High High
Morphine 3 86.48 High High
Disease Link Frequency Relevance Heat
Breast Cancer 2 96.08 Very High Very High Very High
Hepatotoxicity 8 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, multidrug resistance-associated proteins Mrp1, Mrp2, Mrp3, and Mrp4, as well as multidrug resistance proteins Mdr1a and Mdr1b genes, were increased following APAP.
Positive_regulation (increased) of Mrp1 associated with paracetamol
1) Confidence 0.50 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.30 Pain Relevance 0.88
Second, we investigated the role of anionic transporters like the multidrug resistance-associated protein mrp1 and the glucose transporter GLUT-1.
Positive_regulation (resistance-associated) of mrp1
2) Confidence 0.41 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12950465 Disease Relevance 0 Pain Relevance 0.38
With the exceptions of Oatp1a1, Ntcp, and Mrp1, these data mirror previous results suggesting that the solution used to dissolve APAP may alter the susceptibility of mice to hepatotoxicity, but only minimally change the regulation of transporter gene expression.
Neg (exceptions) Positive_regulation (exceptions) of Mrp1 associated with paracetamol and hepatotoxicity
3) Confidence 0.36 Published 2007 Journal J. Toxicol. Environ. Health Part A Section Abstract Doc Link 17934960 Disease Relevance 0.32 Pain Relevance 0.69

General Comments

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