INT112780

Context Info Confidence 0.46 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 1.85 Pain Relevance 0.78

transport (Slc2a1) transmembrane transporter activity (Slc2a1) plasma membrane (Slc2a1) intracellular (Slc2a1) transmembrane transport (Slc2a1) cytoplasm (Slc2a1)

Anatomy Link Frequency endothelial cells 1 spinal cord 1 adipocytes 1 Slc2a1 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 57 99.30 medulla 28 97.52 Potency 1 87.60 Analgesic 1 87.28 Morphine 3 86.48 withdrawal 1 61.36 Inflammation 10 61.20 Paracetamol 12 50.00 excitatory amino acid 2 48.80 Glutamate 5 42.56

Disease Link Frequency Relevance Heat Obesity 19 99.84 Motor Neuron Diseases 39 98.32 Targeted Disruption 119 95.88 Toxicity 10 90.64 Wound Healing 1 90.52 Diabetes Mellitus 15 87.68 Coronary Artery Disease 48 79.84 Disease 73 79.24 Cerebral Edema 3 71.28 INFLAMMATION 16 61.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HIF-1alpha and Glut-1 levels are increased following APAP poisoning, implying that HIF-1alpha is functional during the pathogenic response to APAP poisoning.

Positive_regulation (increased) of Glut-1

1) Confidence 0.46 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16551773 Disease Relevance 0.06 Pain Relevance 0

In addition, abnormal accumulation of Glut1 and vWF in the vascular endothelial cell was observed at the brainstem and spinal cord of symptomatic A53T mice (Figs. 4G-J), indicating the dysfunction of vascular endothelial cells.

Positive_regulation (accumulation) of Glut1 in endothelial cells associated with targeted disruption, medulla and spinal cord

2) Confidence 0.39 Published 2010 Journal Mol Brain Section Body Doc Link PMC2873589 Disease Relevance 0.41 Pain Relevance 0.32

Although additional experiments such as quantitative analysis of Glut-1 distribution and density in the endothelial plasma membranes are needed to elucidate the regulatory mechanisms of Glut-1 expression in the spinal cord, the present study indicates that alteration of Glut-1 could be involved in the pathogenesis of ALS.

Positive_regulation (alteration) of Glut-1 in spinal cord associated with motor neuron diseases and spinal cord

3) Confidence 0.37 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2075163 Disease Relevance 0.51 Pain Relevance 0.08

Hypoxia inducible factor (HIF)-1alpha and Glucose Transporter 1 (Glut-1) levels were determined by Western blot.

Positive_regulation (inducible) of Glut-1

4) Confidence 0.31 Published 2006 Journal Acad Emerg Med Section Body Doc Link 16551773 Disease Relevance 0.09 Pain Relevance 0

Second, we investigated the role of anionic transporters like the multidrug resistance-associated protein mrp1 and the glucose transporter GLUT-1.

Positive_regulation (resistance-associated) of GLUT-1

5) Confidence 0.27 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12950465 Disease Relevance 0 Pain Relevance 0.38

In mice, FGF-21 is expressed predominantly in the liver and stimulates glucose uptake through the induction of GLUT1 in adipocytes [8].

Positive_regulation (induction) of GLUT1 in adipocytes associated with obesity

6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012070 Disease Relevance 0.72 Pain Relevance 0

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