INT112783

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Context Info
Confidence 0.40
First Reported 2003
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 6.82
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELE) cell adhesion (SELE) plasma membrane (SELE)
Anatomy Link Frequency
monocyte 4
endothelial cells 4
SELE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 182 99.04 Very High Very High Very High
metalloproteinase 22 86.32 High High
Nicotine 20 86.16 High High
interstitial cystitis 1 81.20 Quite High
Analgesic 1 76.84 Quite High
Inflammatory response 16 64.40 Quite High
cytokine 28 58.64 Quite High
chemokine 22 55.92 Quite High
Morphine 2 50.00 Quite Low
isoflurane 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 213 100.00 Very High Very High Very High
Nicotine Addiction 418 99.12 Very High Very High Very High
INFLAMMATION 200 99.04 Very High Very High Very High
Diabetic Retinopathy 2 98.64 Very High Very High Very High
Diabetic Angiopathy 4 98.12 Very High Very High Very High
Diabetes Mellitus 204 97.94 Very High Very High Very High
Increased Venous Pressure Under Development 69 94.16 High High
Pulmonary Disease 144 91.20 High High
Injury 10 90.60 High High
Interstitial Cystitis 1 81.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DMSO did not affect expression of E-selectin on endothelial cells in the presence of TNF-alpha.
Neg (not) Regulation (affect) of Gene_expression (expression) of E-selectin in endothelial cells
1) Confidence 0.40 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 12951474 Disease Relevance 0.44 Pain Relevance 0.42
None of the four agents had an effect on TNF-alpha induced E-selectin expression.
Regulation (effect) of Gene_expression (expression) of E-selectin
2) Confidence 0.38 Published 2008 Journal Anesthesiology Section Body Doc Link 18212564 Disease Relevance 0.06 Pain Relevance 0
Adams et al. [102] were able to show upregulation of ICAM-1 (but not VCAM-1 or E-selectin) expression on HUVECs exposed to smokers' serum, and to confirm increased monocyte-endothelium adhesion in smokers selected to exhibit no other major risk factor for vascular disease.
Regulation (upregulation) of Gene_expression (expression) of E-selectin in monocyte associated with nicotine addiction, increased venous pressure under development and adhesions
3) Confidence 0.30 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.85 Pain Relevance 0.18
Adams et al. [102] were able to show upregulation of ICAM-1 (but not VCAM-1 or E-selectin) expression on HUVECs exposed to smokers' serum, and to confirm increased monocyte-endothelium adhesion in smokers selected to exhibit no other major risk factor for vascular disease.
Regulation (upregulation) of Gene_expression (expression) of E-selectin in monocyte associated with nicotine addiction, increased venous pressure under development and adhesions
4) Confidence 0.30 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.85 Pain Relevance 0.18
Endothelial dysfunction was an early manifestation of vascular disease in type 2 diabetes but late in the course of type 1 diabetes (Clarkson et al 1996), furthermore studies have shown that the levels of cVCAM-1 were more markedly elevated in type 1 diabetes patients with diabetic retinopathy than in those patients with micro- or macroalbuminuria, whereas no difference in cICAM-1 and cELAM-1 levels was apparent regarding the clinical status of diabetic microangiopathy (Fasching et al 1996).
Neg (no) Regulation (difference) of Gene_expression (levels) of cELAM-1 associated with diabetic angiopathy, diabetes mellitus, diabetic retinopathy and increased venous pressure under development
5) Confidence 0.12 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 1.40 Pain Relevance 0
Shen and co-workers (1996) have shown that cigarette smoke condensate induces the expression of a subset of cell adhesion molecules, such as intercellular adhesion molecule (ICAM-1), endothelial leukocyte adhesion molecule 1 (ELAM-1), and vascular cell adhesion molecule (VCAM-1) in human umbilical vascular endothelial cells associated with an increase in the binding activity of NF-?
Regulation (intercellular) of Gene_expression (expression) of adhesion molecule 1 in endothelial cells associated with adhesions
6) Confidence 0.02 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.23 Pain Relevance 0.10

General Comments

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