INT112784

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 7.84
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IFNG) extracellular region (IFNG)
Anatomy Link Frequency
astrocytes 6
microglia 2
IFNG (Homo sapiens)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 50 100.00 Very High Very High Very High
spastic colon 14 99.60 Very High Very High Very High
cytokine 31 91.04 High High
Serotonin 2 89.76 High High
glial activation 8 86.16 High High
Inflammation 44 85.52 High High
Hippocampus 4 75.04 Quite High
Thalamus 4 73.12 Quite High
Pain 14 65.44 Quite High
amygdala 36 65.36 Quite High
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

11 99.60 Very High Very High Very High
Aging 10 99.58 Very High Very High Very High
Disease 71 96.16 Very High Very High Very High
Melanoma 17 94.96 High High
Necrosis 6 93.88 High High
Cv Unclassified Under Development 4 93.64 High High
Cancer 183 93.52 High High
Injury 6 93.12 High High
Pancreatitis 17 89.36 High High
Reprotox - General 3 27 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we report that administration of double-stranded RNA, a classical inducer of interferon-gamma (IFN-gamma), causes rapid and persistent activation of microglia and astrocytes, as well as induction of interleukin-1beta (IL-beta) and nitric oxide synthase.
Positive_regulation (causes) of Positive_regulation (inducer) of interferon-gamma in astrocytes
1) Confidence 0.49 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 0.95 Pain Relevance 0.23
In the present study, we report that administration of double-stranded RNA, a classical inducer of interferon-gamma (IFN-gamma), causes rapid and persistent activation of microglia and astrocytes, as well as induction of interleukin-1beta (IL-beta) and nitric oxide synthase.
Positive_regulation (causes) of Positive_regulation (inducer) of IFN-gamma in astrocytes
2) Confidence 0.49 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 0.95 Pain Relevance 0.23
Compared to omnivore subjects, the entire sample of vegetarians and vegans had more significant activations (p<0.05, FWE) of the bilateral IFG (MNI space coordinates: ?
Positive_regulation (activations) of Positive_regulation (bilateral) of IFG
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877098 Disease Relevance 0 Pain Relevance 0.08
Increased activation in the ACC and left IFG in vegetarians and vegans during human and animal suffering view is likely to reflect a stronger empathic response in the first two groups.
Positive_regulation (Increased) of Positive_regulation (activation) of IFG associated with anterior cingulate cortex
4) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877098 Disease Relevance 0.07 Pain Relevance 0.27
In a previous study investigating age-related changes in language comprehension using the same task (Tyler et al., 2010) ageing was associated with increased right IFG activation homologous to the left-hemisphere activation produced by younger subjects in the context of syntactic processing.
Positive_regulation (increased) of Positive_regulation (activation) of IFG associated with aging
5) Confidence 0.39 Published 2010 Journal Brain Section Body Doc Link PMC2965424 Disease Relevance 0.15 Pain Relevance 0
In the present study, we report that administration of double-stranded RNA, a classical inducer of interferon-gamma (IFN-gamma), causes rapid and persistent activation of microglia and astrocytes, as well as induction of interleukin-1beta (IL-beta) and nitric oxide synthase.
Positive_regulation (causes) of in microglia Positive_regulation (inducer) of interferon-gamma in astrocytes
6) Confidence 0.17 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 0.95 Pain Relevance 0.23
In the present study, we report that administration of double-stranded RNA, a classical inducer of interferon-gamma (IFN-gamma), causes rapid and persistent activation of microglia and astrocytes, as well as induction of interleukin-1beta (IL-beta) and nitric oxide synthase.
Positive_regulation (causes) of in microglia Positive_regulation (inducer) of IFN-gamma in astrocytes
7) Confidence 0.17 Published 2003 Journal Glia Section Abstract Doc Link 12951652 Disease Relevance 0.95 Pain Relevance 0.23
The primary aim of this study was to test the hypothesis that IBS is associated with increased tryptophan (Trp) catabolism along the Kyn pathway due to increased IFN-gamma levels.
Positive_regulation (increased) of Positive_regulation (increased) of IFN-gamma associated with spastic colon
8) Confidence 0.09 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18823288 Disease Relevance 0.23 Pain Relevance 0.85
cHSP60 and cHSP10 stimulation results in significant increase in IFN-gamma (P = 0.006 and P = 0.04 respectively) and IL-10 levels (P = 0.04) in infertile group as compared to fertile group.
Positive_regulation (results) of Positive_regulation (increase) of IFN-gamma
9) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2412883 Disease Relevance 1.10 Pain Relevance 0.08
The antitumor effect appeared to be mediated through induction of interferon-gamma.
Positive_regulation (mediated) of Positive_regulation (induction) of interferon-gamma
10) Confidence 0.04 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 1.02 Pain Relevance 0
CD4+ cells produced increased levels of interferon gamma compared with controls, but IL-4 was not increased [77].
Positive_regulation (increased) of Positive_regulation (levels) of interferon gamma
11) Confidence 0.02 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 0.95 Pain Relevance 0

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