INT112823

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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.49
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPK14) nucleoplasm (MAPK14) signal transduction (MAPK14)
nucleus (MAPK14) response to stress (MAPK14) cytoplasm (MAPK14)
MAPK14 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 6 99.92 Very High Very High Very High
Central nervous system 21 99.04 Very High Very High Very High
adenocard 3 98.24 Very High Very High Very High
Osteoarthritis 103 96.00 Very High Very High Very High
cINOD 1 94.48 High High
Inflammation 82 90.48 High High
Arthritis 20 88.00 High High
Pain 5 87.48 High High
Inflammatory response 6 72.12 Quite High
cytokine 42 67.44 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 104 96.00 Very High Very High Very High
INFLAMMATION 93 90.48 High High
Disease 22 88.76 High High
Arthritis 21 88.00 High High
Pain 4 87.48 High High
Disease Progression 5 79.60 Quite High
Stress 5 58.08 Quite High
Injury 2 48.72 Quite Low
Targeted Disruption 5 46.40 Quite Low
Cancer 8 42.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced production of MMPs by blocking the activation of p38-MAPK and the transcription factor NF-?
Negative_regulation (blocking) of Positive_regulation (activation) of p38 associated with metalloproteinase
1) Confidence 0.36 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991031 Disease Relevance 0.92 Pain Relevance 0.55
No decrease was observed in interleukin-1beta-induced p38 mitogen-activated protein kinase, extracellular signal-related kinase or cJun N-terminal kinase activation.
Neg (No) Negative_regulation (decrease) of Positive_regulation (activation) of p38
2) Confidence 0.23 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0 Pain Relevance 0.22
However, in vivo evidence supporting p38?
Negative_regulation (evidence) of Positive_regulation (supporting) of p38
3) Confidence 0.14 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604896 Disease Relevance 0.46 Pain Relevance 0.40
Activation of p38 was also significantly reduced in the LPS treated synoviocytes, and SNP treated Raw 264.7 cells and synoviocytes, but the expression ERK and p38 was also reduced, indicating that blocking of the activation of p38 and ERK was not specific (Fig. 1A and 1B).
Negative_regulation (blocking) of Positive_regulation (activation) of p38
4) Confidence 0.10 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.05 Pain Relevance 0.03
Activation of p38 was also significantly reduced in the LPS treated synoviocytes, and SNP treated Raw 264.7 cells and synoviocytes, but the expression ERK and p38 was also reduced, indicating that blocking of the activation of p38 and ERK was not specific (Fig. 1A and 1B).
Negative_regulation (reduced) of Positive_regulation (Activation) of p38
5) Confidence 0.07 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2442592 Disease Relevance 0.06 Pain Relevance 0.03

General Comments

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