INT11283

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Context Info
Confidence 0.57
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.80
Pain Relevance 2.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm1) plasma membrane (Grm1) nucleus (Grm1)
signal transducer activity (Grm1)
Anatomy Link Frequency
neurons 1
Grm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 4 98.82 Very High Very High Very High
Dorsal horn 7 98.22 Very High Very High Very High
primary afferent fibers 3 96.78 Very High Very High Very High
antagonist 9 96.24 Very High Very High Very High
c fibre 1 95.00 High High
isoflurane 4 94.88 High High
Adelta 1 94.84 High High
anesthesia 8 94.00 High High
Analgesic 1 88.84 High High
Glutamate 5 82.40 Quite High
Disease Link Frequency Relevance Heat
Paralysis 5 97.60 Very High Very High Very High
Stress 2 86.24 High High
Anxiety Disorder 1 82.88 Quite High
Targeted Disruption 1 74.16 Quite High
Fever 1 73.04 Quite High
Nociception 1 5.00 Very Low Very Low Very Low
Catalepsy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
DHPG-induced depolarization desensitized; blockade of mGluR1 prevented the desensitization.
Negative_regulation (blockade) of mGluR1
1) Confidence 0.57 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17959799 Disease Relevance 0.07 Pain Relevance 0.35
Ecw, Ers, Rcw, and Rrs decreased slightly with increasing VT, but RL and EL were independent of VT.
Negative_regulation (decreased) of Rcw
2) Confidence 0.08 Published 1993 Journal J. Appl. Physiol. Section Abstract Doc Link 8335558 Disease Relevance 0.16 Pain Relevance 0
In all conditions, Ers, Ecw, El, Rrs, and Rcw decreased at 800 ml tidal volume compared with 250 ml; Rl showed a similar decrease in awake measurements only.
Negative_regulation (decreased) of Rcw
3) Confidence 0.04 Published 1992 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 1546830 Disease Relevance 0.25 Pain Relevance 0.75
In the present study we have investigated a slow excitatory postsynaptic current (EPSC), elicited by a brief high intensity (at Adelta/C fiber strength) and high frequency (20 or 100 Hz) stimulation of primary afferent fibers (PAFs) using whole-cell patch-clamp recordings from neurons located in the DH (laminae II-V) in spinal cord slices of young rats and wild-type and gene-targeted mice lacking mGluR1 subtype.
Negative_regulation (lacking) of mGluR1 in neurons associated with c fibre, primary afferent fibers, adelta, dorsal horn and spinal cord
4) Confidence 0.03 Published 2008 Journal Neuroscience Section Abstract Doc Link 18554818 Disease Relevance 0 Pain Relevance 0.94
FTIDC selectively blocked methamphetamine-induced hyperlocomotion and disruption of prepulse inhibition, whereas MPEP and LY379268 did not alter those behaviors, suggesting that pharmacological blockade of mGluR1 could result in antipsychotic-like effects.
Negative_regulation (blockade) of mGluR1
5) Confidence 0.03 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18487514 Disease Relevance 0.31 Pain Relevance 0.59

General Comments

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