INT112837

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Context Info
Confidence 0.17
First Reported 2003
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.81
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GPX1) mitochondrion (GPX1) small molecule metabolic process (GPX1)
oxidoreductase activity (GPX1) cytoplasm (GPX1)
GPX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 94.68 High High
Osteoarthritis 1 81.32 Quite High
Inflammatory response 1 64.48 Quite High
COX2 1 25.00 Low Low
alcohol 6 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cataract 26 97.44 Very High Very High Very High
Hemolysis 27 89.84 High High
Hyperhomocysteinemia 15 89.28 High High
Aids-related Complex 64 87.80 High High
Hematuria 4 85.40 High High
Osteoarthritis 1 81.32 Quite High
Thrombosis Related Under Development 3 78.52 Quite High
Hemolytic Anemia 9 72.88 Quite High
Hypertension 2 71.68 Quite High
Proteinuria 1 70.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytosolic GPx (GPx-1) uses GSH as reducing substrate and has been shown to play a central role in hydrogen peroxide detoxification and, consequently, against cataract formation.
Regulation (role) of GPx-1 associated with cataract
1) Confidence 0.17 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2974697 Disease Relevance 0.57 Pain Relevance 0
There were no significant difference in CAT, GSHPx activities, and MDA levels before and after treatment in each group.
Neg (no) Regulation (difference) of GSHPx
2) Confidence 0.09 Published 2003 Journal Drug Chem Toxicol Section Abstract Doc Link 12953657 Disease Relevance 0.15 Pain Relevance 0.25
A recent discovery of homocysteine's effect on the down-regulation of cellular glutathione peroxidase-1 activity implicated its role in facilitating the accumulation of reactive oxygen species [10], which may subsequently instigate the oxidative vulnerability of sulfhydryl groups of hemoglobin and thus lead to hemoglobin precipitates within the RBC.
Regulation (regulation) of glutathione peroxidase-1
3) Confidence 0.03 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2626597 Disease Relevance 1.09 Pain Relevance 0

General Comments

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