INT112842

Context Info Confidence 0.00 First Reported 2003 Last Reported 2003 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0 Pain Relevance 0.81

plasma membrane (Pdyn, Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)

Pdyn (Mus musculus) Oprd1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 8 100.00 Kappa opioid receptor 14 96.28 Dynorphin 4 86.16 Opioid 2 75.00 Delta opioid receptors 4 25.00 agonist 2 25.00

|}

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Based on the hypothesis that the spatial orientation of the aromatic ring at position 4 of Dyn A is important for opioid receptor affinity and selectivity, a series of Dyn A analogues with various Phe derivatives substituted at position 4 were synthesized and evaluated for their opioid receptor affinity and activity.

Positive_regulation (important) of Dyn Binding (affinity) of opioid receptor associated with opioid receptor

1) Confidence 0.00 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12954053 Disease Relevance 0 Pain Relevance 0.41

Based on the hypothesis that the spatial orientation of the aromatic ring at position 4 of Dyn A is important for opioid receptor affinity and selectivity, a series of Dyn A analogues with various Phe derivatives substituted at position 4 were synthesized and evaluated for their opioid receptor affinity and activity.

Positive_regulation (important) of Dyn Binding (affinity) of opioid receptor associated with opioid receptor

2) Confidence 0.00 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12954053 Disease Relevance 0 Pain Relevance 0.40

General Comments

This test has worked.