INT112842

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Context Info
Confidence 0.00
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pdyn, Oprd1) cytoplasm (Oprd1) signal transducer activity (Oprd1)
Pdyn (Mus musculus)
Oprd1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 8 100.00 Very High Very High Very High
Kappa opioid receptor 14 96.28 Very High Very High Very High
Dynorphin 4 86.16 High High
Opioid 2 75.00 Quite High
Delta opioid receptors 4 25.00 Low Low
agonist 2 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on the hypothesis that the spatial orientation of the aromatic ring at position 4 of Dyn A is important for opioid receptor affinity and selectivity, a series of Dyn A analogues with various Phe derivatives substituted at position 4 were synthesized and evaluated for their opioid receptor affinity and activity.
Positive_regulation (important) of Dyn Binding (affinity) of opioid receptor associated with opioid receptor
1) Confidence 0.00 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12954053 Disease Relevance 0 Pain Relevance 0.41
Based on the hypothesis that the spatial orientation of the aromatic ring at position 4 of Dyn A is important for opioid receptor affinity and selectivity, a series of Dyn A analogues with various Phe derivatives substituted at position 4 were synthesized and evaluated for their opioid receptor affinity and activity.
Positive_regulation (important) of Dyn Binding (affinity) of opioid receptor associated with opioid receptor
2) Confidence 0.00 Published 2003 Journal J. Med. Chem. Section Abstract Doc Link 12954053 Disease Relevance 0 Pain Relevance 0.40

General Comments

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