INT112845

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Context Info
Confidence 0.12
First Reported 2003
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.14
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Nkx2-2) nucleus (Nkx2-2) molecular_function (Nkx2-2)
transcription factor binding (Nkx2-2)
Nkx2-2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 15 100.00 Very High Very High Very High
antagonist 5 100.00 Very High Very High Very High
Dopamine 8 97.08 Very High Very High Very High
ischemia 1 71.28 Quite High
Potency 2 68.32 Quite High
substance P 1 67.84 Quite High
Neuropeptide 2 59.84 Quite High
Bioavailability 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 1 71.28 Quite High
Hypoxia 1 70.24 Quite High
Increased Venous Pressure Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with CGRP 8-37 (CGRP receptor antagonist) and NK-1 but not NK-2 nor NK-3 receptor antagonists significantly reduced the HABF by 43% (p< 0.05) and 25% (p< 0.05) as compared to the HABF value in the control HABR group.
Neg (not) Negative_regulation (reduced) of NK-2 Binding (Pretreatment) of associated with antagonist
1) Confidence 0.12 Published 2005 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15795481 Disease Relevance 0.14 Pain Relevance 0.42
N-arachidonoyl-dopamine exerted a potent contractile response of guinea pig isolated bronchi (EC50=12.6 +/- 1.7 microM, Emax=69.2 +/- 2.4% of carbachol Emax), which was blocked by pre-treatment with capsaicin or with the VR1 antagonist capsazepine, as well as by a combination of tachykinin NK1 and NK2 receptor antagonists.
Negative_regulation (blocked) of NK2 Binding (combination) of associated with dopamine, qutenza and antagonist
2) Confidence 0.01 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12954366 Disease Relevance 0 Pain Relevance 1.05

General Comments

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