INT112857

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Context Info
Confidence 0.30
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.41
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (gr)
gr (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 6 99.58 Very High Very High Very High
Hippocampus 1 88.48 High High
antidepressant 4 86.44 High High
sSRI 1 83.04 Quite High
antagonist 1 80.24 Quite High
agonist 1 79.08 Quite High
depression 1 65.00 Quite High
cINOD 1 52.96 Quite High
Neuropeptide 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 1 84.72 Quite High
Affective Disorder 1 72.48 Quite High
Targeted Disruption 1 71.28 Quite High
Stress 1 67.52 Quite High
Depression 1 65.00 Quite High
INFLAMMATION 1 52.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both hippocampal cell proliferation and BDNF mRNA expression were down-regulated in GR-i mice, and these alterations were reversed by chronic agomelatine and fluoxetine treatments, whereas GR mRNA down-regulation was reversed only by agomelatine.
Negative_regulation (reversed) of Negative_regulation (down-regulation) of GR associated with fluoxetine
1) Confidence 0.30 Published 2010 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 19775499 Disease Relevance 0.36 Pain Relevance 0.74
Moreover, the inhibitory effect of GR on NF-kappaB transactivation was reduced to approximately 81 and 12% of the WT levels for S651F and 2314insA, respectively.
Negative_regulation (reduced) of Negative_regulation (effect) of GR
2) Confidence 0.03 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954798 Disease Relevance 0.05 Pain Relevance 0.05

General Comments

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