INT11286

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Context Info
Confidence 0.49
First Reported 1983
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.30
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TMED4) endoplasmic reticulum (TMED4) signal transducer activity (TMED4)
Anatomy Link Frequency
uterus 1
muscle 1
TMED4 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 20 99.98 Very High Very High Very High
Somatosensory cortex 55 98.68 Very High Very High Very High
addiction 4 97.52 Very High Very High Very High
isoflurane 8 97.44 Very High Very High Very High
primary somatosensory cortex 34 90.08 High High
Pain 3 81.08 Quite High
Bioavailability 2 77.04 Quite High
halothane 2 75.00 Quite High
magnetoencephalography 24 72.12 Quite High
Analgesic 2 18.04 Low Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 95 97.18 Very High Very High Very High
Paralysis 10 94.64 High High
Body Weight 1 93.40 High High
Apoptosis 22 87.20 High High
Breast Cancer 28 85.04 High High
Cancer 27 75.36 Quite High
Death 4 70.88 Quite High
Osteolysis 5 37.88 Quite Low
Metastasis 10 22.72 Low Low
Bone Cancer 3 10.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that (1) tidal volume dependence of respiratory system properties in the normal range of breathing occurs in the absence of muscle activity; (2) anesthesia increases Ers and (3) respiratory muscle activity appears to be inhibited by isoflurane-N2O anesthesia at end-tidal isoflurane concentration of 0.3 to 0.5% during normocapnia.
Positive_regulation (increases) of Ers in muscle associated with addiction, anesthesia and isoflurane
1) Confidence 0.49 Published 1992 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 1546830 Disease Relevance 0.25 Pain Relevance 0.83
Compared with awake measurements, each elastance tended to increase after anesthesia, but only the increase in Ers was significant.
Positive_regulation (increase) of Ers associated with anesthesia
2) Confidence 0.49 Published 1992 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 1546830 Disease Relevance 0.26 Pain Relevance 0.81
These results indicate that Ers increases substantially during anesthesia, whereas Rrs remains within the normal limits.
Positive_regulation (increases) of Ers associated with anesthesia
3) Confidence 0.31 Published 1983 Journal J Appl Physiol Section Abstract Doc Link 6629937 Disease Relevance 0.35 Pain Relevance 0.59
In kaempferol- and equol-exposed mice the cytosolic alpha-ERs concentration was significantly increased when compared to the solvent control, which is speculated to result in an increased sensitivity of the uterus to subsequently encountered estrogens.
Positive_regulation (increased) of ERs in uterus
4) Confidence 0.13 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852849 Disease Relevance 0.35 Pain Relevance 0.07
Additionally, the ADHD group showed a substantial decrease in SII alpha and beta power during ERD (decreases in power of cortical oscillations below baseline) and ERS (increases in power of cortical oscillations above baseline).
Positive_regulation (increases) of ERS associated with somatosensory cortex and attention deficit hyperactivity disorder
5) Confidence 0.02 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2266931 Disease Relevance 0.57 Pain Relevance 0.59
In fact, this mitogenic effect of clodronate appears to be mediated by the activation of ERs and is completely suppressed by antiestrogens.
Positive_regulation (activation) of ERs
6) Confidence 0.02 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413981 Disease Relevance 0.52 Pain Relevance 0

General Comments

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