INT112867

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 13.22
Pain Relevance 1.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ccnd1) intracellular (Ccnd1) enzyme binding (Ccnd1)
cell cycle (Ccnd1) cell division (Ccnd1) kinase activity (Ccnd1)
Anatomy Link Frequency
bile duct 2
HPAC 2
BxPC-3 2
Ccnd1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 10 99.98 Very High Very High Very High
Bile 26 98.68 Very High Very High Very High
Chronic pancreatitis 15 96.40 Very High Very High Very High
Inflammation 63 88.28 High High
cytokine 22 86.28 High High
Pyramidal cell 2 86.00 High High
cINOD 17 81.44 Quite High
corticosteroid 1 80.56 Quite High
Inflammatory stimuli 2 80.48 Quite High
Kinase C 12 72.16 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 112 99.84 Very High Very High Very High
Carcinoma 5 99.84 Very High Very High Very High
Disease 283 99.48 Very High Very High Very High
Retinoblastoma 7 99.24 Very High Very High Very High
Biliary Cancer 40 99.12 Very High Very High Very High
Adenocarcinoma 37 99.04 Very High Very High Very High
Hepatocellular Cancer 78 98.86 Very High Very High Very High
Apoptosis 410 98.72 Very High Very High Very High
Bile Duct Neoplasms 22 98.68 Very High Very High Very High
Cancer 367 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment with GSH after AAP induced expression of cyclin D1, p21, and PCNA (12-48 h).
Positive_regulation (induced) of Gene_expression (expression) of cyclin D1 associated with paracetamol
1) Confidence 0.56 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954812 Disease Relevance 0.34 Pain Relevance 0.63
They presented that cyclin D1 overexpression was more common in extrahepatic bile duct cancer than in GB cancer.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 in bile duct associated with bile and cancer
2) Confidence 0.52 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.62 Pain Relevance 0.05
On day 1.5, lidocaine upregulated expression of cyclin-D1 and cyclin-dependent kinase inhibitor 1A [p21].
Positive_regulation (upregulated) of Gene_expression (expression) of cyclin-D1
3) Confidence 0.48 Published 2008 Journal Anesth. Analg. Section Body Doc Link 18931217 Disease Relevance 0 Pain Relevance 0
According to their results, cyclin D1 overexpression varied based on anatomic site, and it was less common in GB cancer.
Positive_regulation (overexpression) of Gene_expression (overexpression) of cyclin D1 associated with cancer
4) Confidence 0.38 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2974735 Disease Relevance 1.52 Pain Relevance 0.04
Expression of endogenous Cyclin D1 was increased when cells were transfected with TFII-I-?
Positive_regulation (increased) of Gene_expression (Expression) of Cyclin D1
5) Confidence 0.34 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2865459 Disease Relevance 0 Pain Relevance 0
ERK1/2 activation leads to the expression of cyclin D1 and c-fos, resulting in the phosphorylation of the retinoblastoma protein (pRb), which initiates the progression of the cell cycle (Nofer, Junker, et al 2001).
Positive_regulation (leads) of Gene_expression (expression) of cyclin D1 associated with retinoblastoma
6) Confidence 0.22 Published 2005 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993938 Disease Relevance 1.04 Pain Relevance 0.08
Therefore, we examined cyclin D1, E and A cdk2 activities in TM10 and TM2H cell cultures after 24 h treatment with SAHA because they reflect kinase activities before, during and after the G1 ?
Positive_regulation (during) of Gene_expression (activities) of cyclin D1
7) Confidence 0.19 Published 2001 Journal Breast Cancer Res Section Body Doc Link PMC13923 Disease Relevance 0.08 Pain Relevance 0
Despite complex associations between tumor cells and PanINs, histological and molecular evidence suggests that PanINs can gradually progress to PDAC, bearing genetic traits such as Ras mutations, Cyclin D1 overexpression and loss of p16 expression [41,42].
Positive_regulation (overexpression) of Gene_expression (overexpression) of Cyclin D1 associated with adenocarcinoma and cancer
8) Confidence 0.16 Published 2010 Journal J Transl Med Section Body Doc Link PMC2916894 Disease Relevance 1.05 Pain Relevance 0.26
Cyclin D1 is also overexpressed in pancreatic cancer and this overexpression is associated with a worse prognosis.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Cyclin D1 associated with pancreatic cancer
9) Confidence 0.11 Published 2003 Journal Mol Cancer Section Body Doc Link PMC149419 Disease Relevance 1.29 Pain Relevance 0.24
B also induces the expression of cyclin D1, which helps in G1-to-S-phase progression by binding directly to its promoter(Guttridgeet al.1999).Inhibition of NF?
Positive_regulation (induces) of Gene_expression (expression) of cyclin D1
10) Confidence 0.10 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2745153 Disease Relevance 0.73 Pain Relevance 0.33
was found to inhibit phosphatidylinositol 3-kinase (PI3K)/Akt signaling and retinoblastoma protein (Rb) dephosphorylation [70], induce expression of cyclin D1 [71] and Bcl-xl/Bcl-2 [72], upregulate p21 and p27 [73–75], interact with XIAP [76], upregulate PTEN [77], and enhance the sensitivity of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand- (TRAIL-) induced cell death [78].
Positive_regulation (induce) of Gene_expression (expression) of cyclin D1 associated with necrosis, cancer, apoptosis, retinoblastoma and death
11) Confidence 0.07 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 1.81 Pain Relevance 0.03
More recent study, however, has altered this view and revealed that even p21cip1 proteins are specific inhibitors of Cyclin E- and A-dependent Cdk2, they act as positive regulators of Cyclin D-dependent kinases.31 Thus, the increase of Cyclin D1 level in BxPC-3 cells may be the consequence of the overexpression of p21cip1.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Cyclin D1 in BxPC-3
12) Confidence 0.04 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.13 Pain Relevance 0
However, it is unclear why there was no change of Cyclin D1 level in spite of G1 phase arrest and overexpression of p21cip1 in HPAC cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Cyclin D1 in HPAC
13) Confidence 0.04 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687755 Disease Relevance 0.20 Pain Relevance 0
An increase in cyclin D1 expression has been demonstrated also in A?
Positive_regulation (increase) of Gene_expression (expression) of cyclin D1
14) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.88 Pain Relevance 0.06
results in the upregulation of cyclin D1 expression in carcinoma cells [204].
Positive_regulation (upregulation) of Gene_expression (expression) of cyclin D1 associated with carcinoma
15) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.20 Pain Relevance 0.04
Therefore, we may infer that G1 to S arrest induced by knocking down CIAPIN1 in HCC cells was at least partly mediated by downregulation of cyclinD1 and upregulation p27 expression.


Positive_regulation (upregulation) of Gene_expression (expression) of cyclinD1 associated with hepatocellular cancer
16) Confidence 0.01 Published 2008 Journal Carcinogenesis Section Body Doc Link PMC2516489 Disease Relevance 1.32 Pain Relevance 0

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