INT112872

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Context Info
Confidence 0.42
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.40
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Glyr1) nucleus (Glyr1) DNA binding (Glyr1)
cellular_component (Glyr1)
Anatomy Link Frequency
Neuron 2
PGE2 2
Glyr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 67 99.72 Very High Very High Very High
Spinal cord 227 99.56 Very High Very High Very High
Pain 24 98.68 Very High Very High Very High
IPN 9 98.32 Very High Very High Very High
interneuron 7 97.76 Very High Very High Very High
medulla 25 93.76 High High
Cannabinoid 38 92.40 High High
Inflammation 6 92.16 High High
gABA 115 91.48 High High
Potency 1 85.84 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 5 99.48 Very High Very High Very High
Pain 24 98.68 Very High Very High Very High
Inflammatory Pain 9 98.32 Very High Very High Very High
Targeted Disruption 14 98.04 Very High Very High Very High
Nociception 15 94.64 High High
Lung Cancer 3 92.96 High High
INFLAMMATION 2 92.16 High High
Post-traumatic Stress Disorder 1 77.20 Quite High
Ganglion Cysts 30 66.80 Quite High
Neuropathic Pain 4 60.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We produced knock-in mice bearing the GlyR alpha1 S267Q mutation to assess the in vivo consequences of selectively decreasing GlyR efficacy.
Negative_regulation (decreasing) of GlyR associated with targeted disruption
1) Confidence 0.42 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954867 Disease Relevance 0.62 Pain Relevance 0.21
Here, we demonstrate that inhibition of a specific glycine receptor subtype (GlyR alpha3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization.
Negative_regulation (inhibition) of GlyR in PGE2 associated with ipn
2) Confidence 0.32 Published 2004 Journal Science Section Abstract Doc Link 15131310 Disease Relevance 0.34 Pain Relevance 0.52
Mice deficient in GlyR alpha3 not only lack the inhibition of glycinergic neurotransmission by PGE2 seen in wild-type mice but also show a reduction in pain sensitization induced by spinal PGE2 injection or peripheral inflammation.
Negative_regulation (deficient) of GlyR in PGE2 associated with pain and inflammation
3) Confidence 0.32 Published 2004 Journal Science Section Abstract Doc Link 15131310 Disease Relevance 0.44 Pain Relevance 0.58
Considerable advantages were provided by the apparent expression of only one type of GlyR (comprised of ?
Negative_regulation (type) of GlyR
4) Confidence 0.12 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2889717 Disease Relevance 0.11 Pain Relevance 0.38
We found no evidence for a 'direct effect' of methAEA on GlyR function in either SDH or DDH.
Negative_regulation (effect) of GlyR
5) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0.21 Pain Relevance 0.73
As in the SDH, methAEA significantly reduced GlyR-mediated mIPSC frequency (0.37 ± 0.09 vs. 0.15 ± 0.03 Hz, n = 8) in DDH neurons.
Negative_regulation (reduced) of GlyR in neurons
6) Confidence 0.11 Published 2009 Journal Mol Pain Section Body Doc Link PMC2784755 Disease Relevance 0 Pain Relevance 0.18
It has been shown that reducing GlyR synaptic inhibition can lead to hypersensitivity to pain (Ahmadi et al., 2002; Coull et al., 2003).
Negative_regulation (inhibition) of GlyR associated with pain and hypersensitivity
7) Confidence 0.04 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.47 Pain Relevance 0.49
Targeted knockdown of the GlyR embryonic subunit ?
Negative_regulation (knockdown) of GlyR
8) Confidence 0.03 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0 Pain Relevance 0.44
Neuron restrictive silencing factor has been shown to act as a repressor of the GlyR?
Negative_regulation (repressor) of GlyR in Neuron
9) Confidence 0.02 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2866564 Disease Relevance 0.22 Pain Relevance 0.07

General Comments

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