INT11288

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Context Info
Confidence 0.00
First Reported 1987
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 44
Total Number 47
Disease Relevance 16.69
Pain Relevance 12.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
response to stress (CRH)
Anatomy Link Frequency
cervix 7
plasma 5
pituitary 3
brain 1
adrenal gland 1
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 10 99.98 Very High Very High Very High
carbamazepine 8 99.84 Very High Very High Very High
cocaine 23 99.82 Very High Very High Very High
rheumatoid arthritis 80 99.64 Very High Very High Very High
Inflammation 199 99.60 Very High Very High Very High
Opioid 9 99.60 Very High Very High Very High
Neuropeptide 7 99.40 Very High Very High Very High
substance P 44 99.32 Very High Very High Very High
narcan 43 99.28 Very High Very High Very High
lidocaine 2 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Fatigue 65 100.00 Very High Very High Very High
Hyperaldosteronism 5 99.90 Very High Very High Very High
Infantile Spasms 190 99.64 Very High Very High Very High
Rheumatoid Arthritis 80 99.64 Very High Very High Very High
INFLAMMATION 209 99.60 Very High Very High Very High
Cancer 159 99.40 Very High Very High Very High
Adrenal Insufficiency 7 99.24 Very High Very High Very High
Depression 213 98.78 Very High Very High Very High
Stress 219 98.60 Very High Very High Very High
Pituitary Cancer 21 98.26 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: Eighteen patients with CM-MOH, diagnosed according to the ICHD-II criteria, and 18 healthy controls received an intravenous administration of GHRH, hCRH, and TRH.
Negative_regulation (administration) of hCRH
1) Confidence 0.00 Published 2006 Journal Headache Section Body Doc Link 16643554 Disease Relevance 0.16 Pain Relevance 0
Impaired coping in stressful situations in adult PS monkeys and rodents is associated with dysregulation of the HPA axis, characterized by decreased feedback inhibition of corticotropin-releasing hormone (CRH) and prolonged elevation of plasma glucocorticoids in response to stress.
Negative_regulation (inhibition) of corticotropin-releasing hormone in plasma associated with stress
2) Confidence 0.59 Published 1997 Journal Neurosci Biobehav Rev Section Abstract Doc Link 8994205 Disease Relevance 0.30 Pain Relevance 0.17
Impaired coping in stressful situations in adult PS monkeys and rodents is associated with dysregulation of the HPA axis, characterized by decreased feedback inhibition of corticotropin-releasing hormone (CRH) and prolonged elevation of plasma glucocorticoids in response to stress.
Negative_regulation (inhibition) of CRH in plasma associated with stress
3) Confidence 0.59 Published 1997 Journal Neurosci Biobehav Rev Section Abstract Doc Link 8994205 Disease Relevance 0.30 Pain Relevance 0.17
The obtained results indicate that inhibition of the human CRH gene promoter activity by imipramine and fluoxetine, but not tianeptine, may play a role in a mechanism by which the former drugs attenuate HPA axis activity.
Negative_regulation (inhibition) of CRH gene associated with fluoxetine
4) Confidence 0.59 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.31
Inhibition of CRH gene promoter activity by antidepressant drugs may be a molecular mechanism by which these drugs inhibit the activity of HPA axis.
Negative_regulation (Inhibition) of CRH gene associated with antidepressant
5) Confidence 0.59 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.10 Pain Relevance 0.45
The transport of hCRH could be specifically inhibited by 5 nmol of unlabeled hCRH (t1/2 = 17.7 min) but not by the same dose of the synthetic analog alpha CRH12-41.
Negative_regulation (inhibited) of hCRH
6) Confidence 0.57 Published 1996 Journal Neuroendocrinology Section Abstract Doc Link 8739889 Disease Relevance 0 Pain Relevance 0.16
These combined effects may explain the robust, established clinical effects of ACTH in the therapy of infantile spasms.35 Additionally, suppression of corticotropin-releasing hormone (CRH), an excitant neuropeptide, by ACTH/steroids was proposed as another mechanism for ACTH treatment of infantile spasms.36 However, there is considerable debate about the reasons why ACTH and prednisone are useful in infantile spasms, their mechanism of action, and their long-term effects on brain development.37
Negative_regulation (suppression) of CRH in brain associated with infantile spasms and neuropeptide
7) Confidence 0.57 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695218 Disease Relevance 0.90 Pain Relevance 0.13
However, there were lower basal levels of CRH(1) receptor mRNA in the anterior pituitary of the MOR -/- mice than in wild-type mice and the MOR -/- mice failed to show the cocaine-induced decreases in CRH(1) receptor mRNA found in the wild-type mice.
Negative_regulation (decreases) of CRH in anterior pituitary associated with mu opioid receptor and cocaine
8) Confidence 0.57 Published 2002 Journal Synapse Section Abstract Doc Link 12125043 Disease Relevance 0.13 Pain Relevance 1.05
However, our immunohistochemical analysis revealed no clear reduction in the levels of the CRH-BP, CRH-R1 and CRH-R2 proteins in connection with pregnancy, which indicates that there may be no change in physiological function.
Neg (no) Spec (clear) Negative_regulation (reduction) of CRH
9) Confidence 0.56 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.08 Pain Relevance 0.06
Thus, the reduction in CRF reported was clinically as well as statistically significant.
Negative_regulation (reduction) of CRF associated with fatigue
10) Confidence 0.47 Published 2010 Journal Annals of Oncology Section Body Doc Link PMC2826100 Disease Relevance 1.42 Pain Relevance 0.18
Imipramine and fluoxetine present in the medium for 5 days, in a concentration-dependent manner (3-30 microM) inhibited the basal activity of CRH gene promoter, while tianeptine was inactive.
Negative_regulation (inhibited) of CRH gene associated with fluoxetine
11) Confidence 0.43 Published 2002 Journal Pol J Pharmacol Section Abstract Doc Link 12866730 Disease Relevance 0 Pain Relevance 0.31
Moreover, imipramine and fluoxetine, but not tianeptine, showed moderate inhibitory effect on CRH gene promoter activity also in AtT-20 cell line, commonly used in CRH gene regulation studies.
Negative_regulation (effect) of CRH gene in AtT-20 associated with fluoxetine
12) Confidence 0.43 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 14735130 Disease Relevance 0.08 Pain Relevance 0.50
Opioids have been shown to inhibit CRF release.
Negative_regulation (inhibit) of CRF associated with opioid
13) Confidence 0.42 Published 1988 Journal Int. J. Neurosci. Section Abstract Doc Link 3165969 Disease Relevance 0.42 Pain Relevance 0.45
We next determined the effect of blocking both central and peripheral opioid receptors with naloxone and, when compared to the naloxone methiodide pre-treated group, a further 60% decrease in Fos-IR mPVN CRH neurons induced by IL-1beta was detected, which was attributed to block of central opioid receptors.
Negative_regulation (decrease) of CRH in neurons associated with narcan and opioid receptor
14) Confidence 0.42 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15993445 Disease Relevance 0.37 Pain Relevance 1.15
Available clinical data support the potential therapeutic efficacy of pharmacological agents which block the CRF(1) receptor.
Negative_regulation (block) of CRF
15) Confidence 0.42 Published 2007 Journal CNS Neurol Disord Drug Targets Section Abstract Doc Link 17511614 Disease Relevance 1.45 Pain Relevance 0.31
This analysis revealed down-regulation of the levels of both CRH-R2 and CRH-BP mRNA in the cervix in connection with labor.
Negative_regulation (regulation) of CRH in cervix
16) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.09 Pain Relevance 0.20
The down-regulation of CRH-BP, CRH-R1 and CRH-R2 in the pregnant uterus could be related to the elevated levels of CRH in maternal plasma or, possibly, less CRH effect is needed in pregnancy than in a non-pregnant state.
Negative_regulation (regulation) of CRH in plasma
17) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.06 Pain Relevance 0
The most pronounced down-regulation of CRH-BP and CRH-R2 occurs in the cervix during labor, irrespective of gestational age.
Negative_regulation (regulation) of CRH in cervix
18) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0 Pain Relevance 0.03
The most pronounced down-regulation of CRH-BP and CRH-R2 occurs in the cervix during labor, irrespective of gestational age.
Negative_regulation (regulation) of CRH in cervix
19) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0 Pain Relevance 0.03
This decrease in cervical CRH-BP, both at the mRNA and protein levels at the time of labor is associated with a similar decrease in the maternal plasma [15], which means that more CRH is bioavailable in cervix and can act on the receptors there.
Negative_regulation (decrease) of CRH in cervix
20) Confidence 0.41 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1513580 Disease Relevance 0.13 Pain Relevance 0.15

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