INT112880

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 1.97
Pain Relevance 1.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnaq) signal transduction (Gnaq) plasma membrane (Gnaq)
GTPase activity (Gnaq) protein complex (Gnaq) signal transducer activity (Gnaq)
Anatomy Link Frequency
endothelium 2
internal 1
thalamus 1
Gnaq (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 98.96 Very High Very High Very High
agonist 601 98.22 Very High Very High Very High
Serotonin 48 98.04 Very High Very High Very High
bradykinin 70 97.96 Very High Very High Very High
Thalamus 4 97.38 Very High Very High Very High
antagonist 190 94.36 High High
Pain 11 93.52 High High
Kinase C 127 90.04 High High
adenocard 57 76.24 Quite High
COX2 9 76.08 Quite High
Disease Link Frequency Relevance Heat
Asthma 301 99.50 Very High Very High Very High
Bordatella Infection 27 94.48 High High
Pain 16 93.52 High High
Nociception 10 91.20 High High
Targeted Disruption 54 80.64 Quite High
Starvation 7 78.32 Quite High
Inflammatory Pain 3 75.00 Quite High
Occupational Lung Diseases 63 73.44 Quite High
Pressure And Volume Under Development 14 69.96 Quite High
Diabetes Mellitus 8 67.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mouse thalamus also has been shown to express a high level of metabotropic glutamate receptor type 1 (mGluR1), which stimulates PLCbetas through activation of Galphaq/11 protein.
Positive_regulation (activation) of Galphaq in thalamus associated with glutamate receptor and thalamus
1) Confidence 0.49 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954872 Disease Relevance 0.80 Pain Relevance 0.47
-subunit Gqi4myr, resulted in dose-dependent increases in CREB activity.
Positive_regulation (increases) of Gqi4myr
2) Confidence 0.13 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2839267 Disease Relevance 0.09 Pain Relevance 0
-mediated activation of COX-2 that occurs solely via the Gq activation of InsP, the PGE2 regulation of COX-2 in FPS cells is mediated by the synergistic effects of the cAMP and InsP second messenger systems via the PKA-EGFR-ERK1/2 pathway.
Positive_regulation (activation) of Gq
3) Confidence 0.08 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0 Pain Relevance 0.05
Both thrombin (capable of activating Gq through protease-activated receptors (PARs) [34]) and lysophosphatidic acid (LPA) (capable of activating Gq through endothelium differentiation gene (EDG) receptors) are strong stimulators of cultured ASM DNA synthesis and cell proliferation.
Positive_regulation (activating) of Gq in endothelium
4) Confidence 0.08 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.13
subfamily tend to mediate the actions of activated Gq [29].
Positive_regulation (activated) of Gq
5) Confidence 0.07 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.10
On one level we can consider the contribution of a disrupted balance of procontractile and prorelaxant stimuli accessible to ASM, whereby 1) an increase in procontractile stimuli in the asthmatic airway promotes greater activation of GPCRs (Gq- and Gi-coupled receptors) mediating contraction, or 2) a reduction in agonist levels serving Gs-coupled receptor activation diminishes prorelaxant signaling.
Positive_regulation (activation) of Gq associated with asthma and agonist
6) Confidence 0.06 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.63 Pain Relevance 0.20
Other effects reported to involve Gq activation by ASM GPCRs include actin polymerization induced by LPA, endothelin, or carbachol, which appears to occur via a Rho-dependent mechanism [40].
Positive_regulation (activation) of Gq
7) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.05 Pain Relevance 0.24
Both thrombin (capable of activating Gq through protease-activated receptors (PARs) [34]) and lysophosphatidic acid (LPA) (capable of activating Gq through endothelium differentiation gene (EDG) receptors) are strong stimulators of cultured ASM DNA synthesis and cell proliferation.
Positive_regulation (activating) of Gq in endothelium
8) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.13
Although numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates.
Positive_regulation (activates) of Gq
9) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.08 Pain Relevance 0.07
To characterize them, we used RS23597 because it activated Gq signaling of Rs1 but not the wildtype 5-HT4 receptor, as measured by calcium mobilization assays (Figure S3C).
Neg (not) Positive_regulation (activated) of Gq
10) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.04
Therefore, we could use drugs with distinct chemical structures (Figure S1) to activate Gs or Gs/Gq signaling of Rs1.
Positive_regulation (activate) of Gq
11) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.04
None of the other 12 chimeras showed enhanced Gq signaling, even when multiple internal segments were combined.
Positive_regulation (enhanced) of Gq in internal
12) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.04
An agonist-bound receptor undergoes a conformational change that promotes its association with and activation of the heterotrimeric G protein Gq.
Positive_regulation (activation) of Gq associated with agonist
13) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.06 Pain Relevance 0.05
Surprisingly, the D66A and D66N mutations also abolished zacopride-induced Gq signaling (Figure 6C).
Positive_regulation (induced) of Gq
14) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0.07 Pain Relevance 0.04
Since Gq signaling of Rs1-C-5-HT2C was activated by cisapride, zacopride, and RS23597 but not by serotonin, we named it Rs1.1 (Table 1).
Neg (not) Positive_regulation (activated) of Gq associated with serotonin
15) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.05
Furthermore, the activation of Gq proteins itself seems to trigger a multifaceted and complex response in which not only the PLC/InsP3/PKC pathway, but also the phosphatidylinositol-3-kinase/AKT/endothelial nitric oxide synthase pathway is stimulated, at least at the peripheral level [125].
Positive_regulation (activation) of Gq
16) Confidence 0.04 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.06 Pain Relevance 0.08
Moreover, several intracellular signaling pathways are activated via Gq.
Positive_regulation (activated) of Gq
17) Confidence 0.03 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.13 Pain Relevance 0.06
These modified GPCRs will help us better study the effect of constitutive Gs signaling and ligand-induced Gs, Gs/Gq, and Gi signaling in vivo.


Positive_regulation (induced) of Gq
18) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.15

General Comments

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