INT112881

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Context Info
Confidence 0.49
First Reported 2003
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.86
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnaq) signal transduction (Gnaq) plasma membrane (Gnaq)
GTPase activity (Gnaq) protein complex (Gnaq) signal transducer activity (Gnaq)
Anatomy Link Frequency
thalamus 2
Gnaq (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 2 99.52 Very High Very High Very High
agonist 57 98.90 Very High Very High Very High
Thalamus 1 97.94 Very High Very High Very High
Pain 7 94.64 High High
IPN 3 75.00 Quite High
Acute pain 1 60.56 Quite High
tail-flick 1 57.20 Quite High
Inflammation 14 43.44 Quite Low
Dorsal horn 1 38.32 Quite Low
Spinal cord 1 36.80 Quite Low
Disease Link Frequency Relevance Heat
Pain 6 94.64 High High
Nociception 4 91.20 High High
Targeted Disruption 7 80.64 Quite High
Inflammatory Pain 3 75.00 Quite High
Starvation 1 61.16 Quite High
INFLAMMATION 13 43.44 Quite Low
Asthma 43 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 9 5.00 Very Low Very Low Very Low
Bronchospasm 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mouse thalamus also has been shown to express a high level of metabotropic glutamate receptor type 1 (mGluR1), which stimulates PLCbetas through activation of Galphaq/11 protein.
Positive_regulation (stimulates) of Positive_regulation (activation) of Galphaq in thalamus associated with glutamate receptor and thalamus
1) Confidence 0.49 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954872 Disease Relevance 0.80 Pain Relevance 0.47
An agonist-bound receptor undergoes a conformational change that promotes its association with and activation of the heterotrimeric G protein Gq.
Positive_regulation (promotes) of Positive_regulation (activation) of Gq associated with agonist
2) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.06 Pain Relevance 0.07

General Comments

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