INT112883

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Context Info
Confidence 0.65
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 6.54
Pain Relevance 4.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hspg2) extracellular region (Hspg2) proteinaceous extracellular matrix (Hspg2)
extracellular matrix organization (Hspg2)
Anatomy Link Frequency
neuronal 1
pituitary 1
VPL 1
olfactory epithelium 1
prefrontal 1
Hspg2 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 8 100.00 Very High Very High Very High
Hyperalgesia 6 99.84 Very High Very High Very High
Kinase C 59 99.70 Very High Very High Very High
antidepressant 78 99.44 Very High Very High Very High
long-term potentiation 90 99.40 Very High Very High Very High
sSRI 182 98.72 Very High Very High Very High
Inflammation 43 98.52 Very High Very High Very High
Neuropathic pain 1 97.84 Very High Very High Very High
depression 109 97.64 Very High Very High Very High
Pain 35 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 8 99.84 Very High Very High Very High
Osteochondroma 80 99.56 Very High Very High Very High
INFLAMMATION 42 98.52 Very High Very High Very High
Neuropathic Pain 3 97.84 Very High Very High Very High
Cancer 132 97.72 Very High Very High Very High
Depression 121 97.64 Very High Very High Very High
Pain 32 96.88 Very High Very High Very High
Targeted Disruption 221 96.84 Very High Very High Very High
Hypopituitarism 14 95.72 Very High Very High Very High
Manic Depressive Disorder 6 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the rat pituitary, laminin, the HSPG perlecan, and type IV collagen. are found inside nonhormonal cells whereas laminin and, to a lesser extent, type IV collagen are found in hormonal cells, suggesting that hormonal cells participate to the elaboration of BM (822).
Gene_expression (found) of perlecan in pituitary
1) Confidence 0.65 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
This may have been caused by the opposite effects of HSPG ablation and RGD insertion; while the former ablates transduction via HSPG, the latter increases delivery through av integrins.
Gene_expression (transduction) of HSPG
2) Confidence 0.47 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936307 Disease Relevance 0.64 Pain Relevance 0
Recently, mutations in the gene Perlecan (HSPG2) encoding the protein heparan sulfate proteoglycan 2, have been found to be responsible for this condition.
Gene_expression (encoding) of HSPG2
3) Confidence 0.41 Published 2003 Journal BMC Neurol Section Body Doc Link PMC166146 Disease Relevance 1.06 Pain Relevance 0
Because TRPM5 and PLC are also expressed in the main olfactory epithelium [37], [38], [50], we determined whether the regulation indeed is mediated by SCCs of the VNO.
Gene_expression ( also exp) of PLC in olfactory epithelium
4) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.16 Pain Relevance 0
These SCCs express transient receptor potential channel M5 (TRPM5) and the phospholipase C (PLC) ?
Gene_expression (express) of PLC associated with trp channel
5) Confidence 0.33 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2912856 Disease Relevance 0.09 Pain Relevance 0.09
These SCCs express transient receptor potential channel M5 (TRPM5) and the phospholipase C (PLC) ?
Gene_expression (express) of PLC associated with trp channel
6) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2912856 Disease Relevance 0.09 Pain Relevance 0.09
Further, we have shown that PLC is involved in both Ca2+ responses in isolated SCCs and in the regulation of stimulus access and that TRPM5 expressed in the SCCs is especially important for limiting the amount of bitter compounds entering the VNOs.
Gene_expression (involved) of PLC
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0 Pain Relevance 0
Third, the PLC inhibitor U73122 suppresses the stimulus-induced Ca2+ responses in SCCs as well as disrupts the regulation on the access of such chemicals.
Gene_expression (suppresses) of PLC
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.20 Pain Relevance 0.08
The PLC inhibitor U73122 and its inactive analogue U73343 (Calbiochem, San Diego, CA) were dissolved in DMSO and diluted into the bath solution at a final concentration of 5 µM for Ca2+ imaging experiment and 10 µM for the dye assay.
Gene_expression (dissolved) of PLC associated with imagery
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0 Pain Relevance 0.36
The antibodies against PLC-?
Gene_expression (antibodies) of PLC
10) Confidence 0.28 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770323 Disease Relevance 0 Pain Relevance 0
We found that the PLC expressed in the SCCs plays an important role in detecting both odorous and bitter substances, and that a functioning TRPM5 is critical for signal transduction of bitter substances, consequently, limiting their access to the VNOs.
Gene_expression (expressed) of PLC
11) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.10 Pain Relevance 0
mice [13], [14], suggesting that there is heterogeneous expression of PLC subtypes in individual cells even within the same neuronal cluster.
Gene_expression (expression) of PLC in neuronal
12) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770323 Disease Relevance 0 Pain Relevance 0.04
Two studies have shown diminished HSPG expression in either osteochondromas or cultured EXT1-/- cells [92,93].
Gene_expression (expression) of HSPG associated with osteochondroma
13) Confidence 0.20 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 1.00 Pain Relevance 0
Phospholipase C (PLC) beta4, one of the four isoforms of PLCbetas, is the sole isoform expressed in the mouse ventral posterolateral thalamic nucleus (VPL), a key station in pain processing.
Gene_expression (expressed) of PLC in VPL associated with pain
14) Confidence 0.14 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954872 Disease Relevance 0.42 Pain Relevance 0.35
Additionally, antidepressant treatment can decrease the expression of PLC?
Gene_expression (expression) of PLC associated with antidepressant
15) Confidence 0.14 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.25 Pain Relevance 0.52
In vivo they form a stable hetero-oligomeric complex that accumulates in the Golgi apparatus, where it is involved in heparan sulphate proteoglycan (HSPG) biosynthesis (reviewed by Esko et al [58]) (Fig. 4).
Gene_expression (biosynthesis) of HSPG
16) Confidence 0.13 Published 2004 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840003 Disease Relevance 0.50 Pain Relevance 0
These results strongly indicate that the intracellular cascade triggered by the stimulation of mGluR5 involves the PLC and that postsynaptic Ca2+ rise is required to induce eCB-LTD, in accord with a role for postsynaptic mGluR5.

2-AG mediates eCB-dependent LTD in the prefrontal cortex

Gene_expression (involves) of PLC in prefrontal associated with depression
17) Confidence 0.12 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.78 Pain Relevance 0.52
q coupling and PLC activation in FPEP2 Ishikawa cells
Gene_expression (activation) of PLC
18) Confidence 0.10 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0
Polymorphisms in PLC?
Gene_expression (Polymorphisms) of PLC
19) Confidence 0.10 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.24 Pain Relevance 0.49
As shown in Fig. 2D, inhibition of PLC using the PLC?
Gene_expression (using) of PLC
20) Confidence 0.09 Published 2010 Journal Cell Signal Section Body Doc Link PMC2791881 Disease Relevance 0 Pain Relevance 0.26

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