INT112891

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 3.98
Pain Relevance 1.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPD1) cytosol (HSPD1) mitochondrion (HSPD1)
extracellular space (HSPD1) cell death (HSPD1) ATPase activity (HSPD1)
Anatomy Link Frequency
endothelium 2
epithelial cells 2
T cells 2
HSPD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 6 99.78 Very High Very High Very High
Crohn's disease 49 97.28 Very High Very High Very High
cINOD 2 88.36 High High
Inflammation 51 86.96 High High
Arthritis 7 84.40 Quite High
Osteoarthritis 3 76.76 Quite High
rheumatoid arthritis 32 74.16 Quite High
cytokine 25 58.24 Quite High
Pain 2 27.68 Quite Low
metalloproteinase 3 18.68 Low Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 6 99.78 Very High Very High Very High
Stress 65 99.72 Very High Very High Very High
Acute Coronary Syndrome 9 99.32 Very High Very High Very High
Coronary Artery Disease 2 98.16 Very High Very High Very High
Increased Venous Pressure Under Development 3 98.00 Very High Very High Very High
Disease 86 97.28 Very High Very High Very High
Shock 14 94.48 High High
Osteoarthritis 6 91.88 High High
Death 7 90.56 High High
Myocardial Infarction 1 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined the effect of HSP60 or HSP70 overexpression on hydrogen peroxide-induced (H2O2) or indomethacin-induced cell damage in the small intestinal epithelial cells.
Spec (examined) Regulation (effect) of Gene_expression (overexpression) of HSP60 in epithelial cells
1) Confidence 0.43 Published 2010 Journal Life Sci. Section Abstract Doc Link 20159025 Disease Relevance 0.26 Pain Relevance 0.18
Shear stress, for example, has been identified as an inducer of HSP60 in endothelial cells [10] and it is conceivable that shear stress might have a role in HSP60 expression in the synovial lining and endothelium.
Spec (might) Regulation (role) of Gene_expression (expression) of HSP60 in endothelium associated with stress
2) Confidence 0.33 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.21 Pain Relevance 0.32
In addition, inflamed biopsies showed upregulation of IL23 and an abundance of HSP60 expression in CD4 positive T cells.
Regulation (abundance) of Gene_expression (expression) of HSP60 in T cells
3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.63 Pain Relevance 0.33
Based on this concept, we evaluated the intimal presence of four pathogens in human coronary atheroma, clinically associated with acute coronary syndromes (ACS) and stable angina (SA), and the effect of pathogen burden on the expression of human heatshock protein 60 (hHSP60), a key protein in (auto-)immune pathogenesis of atherosclerosis.
Regulation (effect) of Gene_expression (expression) of hHSP60 associated with acute coronary syndrome, angina, coronary artery disease and increased venous pressure under development
4) Confidence 0.07 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12955411 Disease Relevance 1.88 Pain Relevance 0.34

General Comments

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