INT112891

Context Info Confidence 0.43 First Reported 2001 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 2 Total Number 4 Disease Relevance 3.98 Pain Relevance 1.17

unfolded protein binding (HSPD1) cytosol (HSPD1) mitochondrion (HSPD1) extracellular space (HSPD1) cell death (HSPD1) ATPase activity (HSPD1)

Anatomy Link Frequency endothelium 2 epithelial cells 2 T cells 2 HSPD1 (Homo sapiens)

Pain Link Frequency Relevance Heat Angina 6 99.78 Crohn's disease 49 97.28 cINOD 2 88.36 Inflammation 51 86.96 Arthritis 7 84.40 Osteoarthritis 3 76.76 rheumatoid arthritis 32 74.16 cytokine 25 58.24 Pain 2 27.68 metalloproteinase 3 18.68

Disease Link Frequency Relevance Heat Cv General 3 Under Development 6 99.78 Stress 65 99.72 Acute Coronary Syndrome 9 99.32 Coronary Artery Disease 2 98.16 Increased Venous Pressure Under Development 3 98.00 Disease 86 97.28 Shock 14 94.48 Osteoarthritis 6 91.88 Death 7 90.56 Myocardial Infarction 1 90.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, we examined the effect of HSP60 or HSP70 overexpression on hydrogen peroxide-induced (H2O2) or indomethacin-induced cell damage in the small intestinal epithelial cells.

Spec (examined) Regulation (effect) of Gene_expression (overexpression) of HSP60 in epithelial cells

1) Confidence 0.43 Published 2010 Journal Life Sci. Section Abstract Doc Link 20159025 Disease Relevance 0.26 Pain Relevance 0.18

Shear stress, for example, has been identified as an inducer of HSP60 in endothelial cells [10] and it is conceivable that shear stress might have a role in HSP60 expression in the synovial lining and endothelium.

Spec (might) Regulation (role) of Gene_expression (expression) of HSP60 in endothelium associated with stress

2) Confidence 0.33 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128883 Disease Relevance 1.21 Pain Relevance 0.32

In addition, inflamed biopsies showed upregulation of IL23 and an abundance of HSP60 expression in CD4 positive T cells.

Regulation (abundance) of Gene_expression (expression) of HSP60 in T cells

3) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765612 Disease Relevance 0.63 Pain Relevance 0.33

Based on this concept, we evaluated the intimal presence of four pathogens in human coronary atheroma, clinically associated with acute coronary syndromes (ACS) and stable angina (SA), and the effect of pathogen burden on the expression of human heatshock protein 60 (hHSP60), a key protein in (auto-)immune pathogenesis of atherosclerosis.

Regulation (effect) of Gene_expression (expression) of hHSP60 associated with acute coronary syndrome, angina, coronary artery disease and increased venous pressure under development

4) Confidence 0.07 Published 2003 Journal Z Kardiol Section Abstract Doc Link 12955411 Disease Relevance 1.88 Pain Relevance 0.34

General Comments

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