INT1129

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Context Info
Confidence 0.35
First Reported 1979
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 69
Total Number 73
Disease Relevance 14.01
Pain Relevance 9.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
reticulum 3
muscle 2
neuronal 2
neurons 2
plasma 1
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 476 100.00 Very High Very High Very High
antagonist 130 100.00 Very High Very High Very High
Inflammation 113 100.00 Very High Very High Very High
nMDA receptor 193 99.76 Very High Very High Very High
agonist 86 99.68 Very High Very High Very High
Pain 43 99.68 Very High Very High Very High
ischemia 19 98.68 Very High Very High Very High
Glutamate 155 98.32 Very High Very High Very High
Clonidine 8 97.62 Very High Very High Very High
Calcium channel 62 96.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 133 100.00 Very High Very High Very High
Immunization 15 100.00 Very High Very High Very High
Acidosis 14 100.00 Very High Very High Very High
Pain 47 99.68 Very High Very High Very High
Adhesions 268 99.58 Very High Very High Very High
Sialadenitis 16 99.30 Very High Very High Very High
Osteoporosis 6 98.96 Very High Very High Very High
Cv Unclassified Under Development 11 98.68 Very High Very High Very High
Overactive Bladder 39 98.48 Very High Very High Very High
Infection 48 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we evaluated ryanodine receptor binding, Ca2+ uptake, the relation between SERCA and uptake, and calsequestrin (Ca2+ storage), in normal, primary IOOA, and secondary IOOA.
Ca2 Binding (binding) of
1) Confidence 0.35 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0 Pain Relevance 0
Ca2+ binds with the protein participating in muscle contraction to induce muscle contraction and is then reabsorbed into the sarcoplasmic reticulum via Ca2+ ATPase.
Ca2 Binding (binds) of in reticulum
2) Confidence 0.35 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.44 Pain Relevance 0
The results suggest that pacemaker [Ca2+]i oscillations in ICCs are produced by close interaction of intracellular Ca2+ release channels, especially inositol 1,4,5-trisphosphate receptor (InsP3R) and Ca2+ influx pathways, presumably corresponding to store-operated type channels.
Ca2 Binding (interaction) of
3) Confidence 0.32 Published 2005 Journal J. Biol. Rhythms Section Abstract Doc Link 15654067 Disease Relevance 0 Pain Relevance 0.11
Autoimmune sialadenitis was induced in PL/J(H-2u) mice by immunization with human carbonic anhydrase II (CAII) [100].
CAII Binding (immunization) of associated with immunization and sialadenitis
4) Confidence 0.31 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.69 Pain Relevance 0.19
Alternatively, a mutant version of apoaequorin could be used in place of the native version inside the transgene, to lower its Ca2+ binding affinity [47].
Ca2 Binding (binding) of
5) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.15 Pain Relevance 0.11
Upon Ca2+ binding, aequorin undergoes a conformational change that oxidizes its substrate coelenterazine (CLZN) and chemiluminescence resonance energy transfer (CRET) to the GFP moiety occurs, with an emission maximum in the green (??
Ca2 Binding (binding) of
6) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.14 Pain Relevance 0.18
GA has a low Ca2+ binding affinity, large dynamic range of light emission, is stable and has little, if any, toxicity, making it a potentially useful reporter for application in BLI studies [13], [14].
Ca2 Binding (affinity) of associated with toxicity and imagery
7) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1991622 Disease Relevance 0.25 Pain Relevance 0.17
These include ryanodine receptor, a Ca2+ release channel which participates in Ca2+ release from sarcoplasmic reticulum into muscle cells, Ca2+-ATPase, which drives Ca2+ uptake, and calsequestrin that binds with Ca2+.8-11 Thus, since Ca2+ uptake by the sarcoplasmic reticulum and Ca2+ release from the sarcoplasmic reticulum play key roles in the regulation of Ca2+ concentrations in muscle cells, the above proteins are important elements in studies on the mechanisms of muscle contraction and relaxation.
Ca2 Binding (binds) of in muscle
8) Confidence 0.29 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.41 Pain Relevance 0
Indeed, alteration of the affinity of CaMKII and Ca2+/CaM significantly affected the Ca2+-mediated CaMKII activation (see Supplementary information).
Ca2 Binding (affinity) of
9) Confidence 0.29 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Knowledge of Ca:Pb and Pb:Ca ratios in different structural and functional compartments of cells is essential for identifying, characterizing, and understanding the significance of Pb2+-Ca2+ interactions.
Ca2 Binding (interactions) of
10) Confidence 0.29 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2718179 Disease Relevance 0.25 Pain Relevance 0.09
Quantitative interactions between Pb2+ and Ca2+ homeostasis in cultured osteoclastic bone cells.
Ca2 Binding (interactions) of associated with osteoporosis
11) Confidence 0.29 Published 1989 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 2718179 Disease Relevance 0.27 Pain Relevance 0.09
Autoimmune sialadenitis was induced in PL/J(H-2u) mice by immunization with human carbonic anhydrase II (CAII) [100].
carbonic anhydrase II Binding (immunization) of associated with immunization and sialadenitis
12) Confidence 0.27 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3018660 Disease Relevance 1.68 Pain Relevance 0.19
Thus, we evaluated ryanodine receptor binding, Ca2+ uptake, the relation between SERCA and uptake, and calsequestrin (Ca2+ storage), in normal, primary IOOA, and secondary IOOA.
Ca2 Binding (binding) of
13) Confidence 0.27 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0 Pain Relevance 0
Calsequestrin is a Ca2+ storage protein that binds Ca2+ within the lumen of the sarcoplasmic reticulum.
Ca2 Binding (binds) of in reticulum
14) Confidence 0.26 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.34 Pain Relevance 0.03
Calsequestrin is a Ca2+ storage protein that binds Ca2+ within the lumen of the sarcoplasmic reticulum.
Ca2 Binding (binds) of in reticulum
15) Confidence 0.26 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.33 Pain Relevance 0.03
These include ryanodine receptor, a Ca2+ release channel which participates in Ca2+ release from sarcoplasmic reticulum into muscle cells, Ca2+-ATPase, which drives Ca2+ uptake, and calsequestrin that binds with Ca2+.8-11 Thus, since Ca2+ uptake by the sarcoplasmic reticulum and Ca2+ release from the sarcoplasmic reticulum play key roles in the regulation of Ca2+ concentrations in muscle cells, the above proteins are important elements in studies on the mechanisms of muscle contraction and relaxation.
Ca2 Binding (binds) of in muscle
16) Confidence 0.26 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.41 Pain Relevance 0
-CaMKII has 10-fold higher affinity for Ca2+/CaM than ?
Ca2 Binding (affinity) of
17) Confidence 0.25 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
The other is downregulation of PDE1 by CaMKII through decreasing the affinity for Ca2+/CaM (Hashimoto et al, 1989), which would facilitate the PP-1 inhibition by phospho-DARPP-32 through augmentation of the PKA activity.
Ca2 Binding (affinity) of
18) Confidence 0.25 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0
Ca2+ imaging and electrophysiology in slice cultures
Ca2 Binding (imaging) of associated with imagery
19) Confidence 0.25 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0.05 Pain Relevance 0.20
Moreover, to reduce interaction of Ca2+ sensing modules with cellular targets, mutant CaM/M13 pairs and the skeletal muscle specific Ca2+ sensing protein troponin were used to engineer novel FCIPs, D3cpv (Palmer et al., 2006) and TN-XXL (Mank et al., 2008), respectively.
Ca2 Binding (interaction) of in skeletal muscle
20) Confidence 0.25 Published 2010 Journal Frontiers in Neural Circuits Section Body Doc Link PMC2866455 Disease Relevance 0 Pain Relevance 0.03

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