INT112908

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Context Info
Confidence 0.77
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 65
Total Number 68
Disease Relevance 1.27
Pain Relevance 16.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
nucleus accumbens 3
neurons 3
striatum 3
neuronal 1
output neurons 1
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 4344 99.92 Very High Very High Very High
Glutamate 1040 99.88 Very High Very High Very High
agonist 60 99.60 Very High Very High Very High
Glutamate receptor 22 99.12 Very High Very High Very High
antagonist 57 99.08 Very High Very High Very High
dopamine receptor 129 98.88 Very High Very High Very High
Nucleus accumbens 227 98.80 Very High Very High Very High
long-term potentiation 284 98.52 Very High Very High Very High
Neurotransmitter 119 97.52 Very High Very High Very High
tetrodotoxin 16 96.40 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 78 99.34 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 49 96.60 Very High Very High Very High
Anxiety Disorder 26 66.52 Quite High
Alcohol Addiction 25 59.16 Quite High
Apoptosis 6 57.08 Quite High
Depression 96 51.52 Quite High
Adhesions 20 49.12 Quite Low
Frailty 2 40.52 Quite Low
Stress 19 34.60 Quite Low
Neuroblastoma 1 14.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, DARPP-32 phosphorylation was abolished by both antagonists.
Phosphorylation (phosphorylation) of DARPP-32 associated with antagonist
1) Confidence 0.77 Published 2010 Journal Addict Biol Section Abstract Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.31
Here we report that an acute ethanol challenge induces a robust phosphorylation of two key signal transduction kinases, AKT and DARPP-32, in the striatum of mice.
Phosphorylation (phosphorylation) of DARPP-32 in striatum
2) Confidence 0.77 Published 2010 Journal Addict Biol Section Abstract Doc Link 20456289 Disease Relevance 0 Pain Relevance 0.31
In this study, we examined the effect of neurotensin on DARPP-32 Thr75 phosphorylation using mouse neostriatal slices.
Phosphorylation (phosphorylation) of DARPP-32
3) Confidence 0.73 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.27
DARPP-32 is also phosphorylated by cyclin-dependent kinase 5 on Thr75, and the phosphorylated form of DARPP-32 at Thr75 inhibits protein kinase (PKA) activity.
Phosphorylation (phosphorylated) of DARPP-32
4) Confidence 0.73 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.26
These results indicate that neurotensin stimulates the release of glutamate by activating a hypothesized unidentified neurotensin receptor, resulting in the dephosphorylation of DARPP-32 at Thr75 by activating NMDA and AMPA receptors expressed at medium spiny neurons.
Phosphorylation (dephosphorylation) of DARPP-32 in neurons associated with glutamate
5) Confidence 0.73 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.37
We have recently reported that neurotensin stimulates the phosphorylation of DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of Mr 32 kDa) at Thr34 (PKA-site) by activating dopamine D1-type receptors in neostriatal neurons.
Phosphorylation (phosphorylation) of DARPP-32 in neurons associated with dopamine
6) Confidence 0.73 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.18
DARPP-32 is also phosphorylated by cyclin-dependent kinase 5 on Thr75, and the phosphorylated form of DARPP-32 at Thr75 inhibits protein kinase (PKA) activity.
Phosphorylation (phosphorylated) of DARPP-32
7) Confidence 0.73 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.21
In agreement with higher levels of phosphorylation of TH, we also find increased levels of phosphorylation of DARPP-32.
Phosphorylation (phosphorylation) of DARPP-32
8) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.33
In particular, neglecting dams have increased optical density for phosphorylated DARPP-32 (pDARPP-32) immunoreactivity within the nucleus accumbens and CP (Fig. 7).
Phosphorylation (phosphorylated) of DARPP-32 in nucleus accumbens associated with nucleus accumbens
9) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.36
The activity of D1-like dopamine receptor-associated processes was investigated by examining the phosphorylation of DARPP-32 in dams with their second litter.
Phosphorylation (phosphorylation) of DARPP-32 associated with dopamine receptor
10) Confidence 0.66 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.35
Pretreatment with a combined neurotensin receptor type 1 (NTR1)/type 2 (NTR2) antagonist, SR142948, reduced the basal level of phospho-Thr75 DARPP-32 and abolished the ability of neurotensin to decrease DARPP-32 Thr75 phosphorylation.
Phosphorylation (phosphorylation) of DARPP-32 associated with antagonist
11) Confidence 0.64 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.40
However, neither an NTR1 antagonist, SR48692, an NTR2 antagonist, levocabastine, nor the two combined affected the basal level and the neurotensin-mediated decrease in DARPP-32 Thr75 phosphorylation.
Phosphorylation (phosphorylation) of DARPP-32 associated with antagonist
12) Confidence 0.64 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.44
Regulation of DARPP-32 Thr75 phosphorylation by neurotensin in neostriatal neurons: involvement of glutamate signalling.
Phosphorylation (phosphorylation) of DARPP-32 in neurons associated with glutamate
13) Confidence 0.64 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.28
Phosphorylation of DARPP-32 is increased by D1-like, but not D2-like, dopamine receptors and is specifically phosphorylated on threonine34 (Thr34) in response to dopamine acting through a cAMP-dependent protein kinase (PKA) [53]–[55].
Phosphorylation (Phosphorylation) of DARPP-32 associated with dopamine and dopamine receptor
14) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.44
In particular, neglecting dams have increased optical density for phosphorylated DARPP-32 (pDARPP-32) immunoreactivity within the nucleus accumbens and CP (Fig. 7).
Phosphorylation (phosphorylated) of pDARPP-32 in nucleus accumbens associated with nucleus accumbens
15) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.36
DARPP-32 is also phosphorylated by cyclin-dependent kinase 5 on Thr75, and the phosphorylated form of DARPP-32 at Thr75 inhibits protein kinase (PKA) activity.
Phosphorylation (form) of DARPP-32
16) Confidence 0.56 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.26
Phosphorylation of DARPP-32, a marker for dopamine D1-like receptor activation, was elevated within nucleus accumbens and caudate-putamen in neglectful versus nurturing dams.


Phosphorylation (Phosphorylation) of DARPP-32 in nucleus accumbens associated with nucleus accumbens and dopamine
17) Confidence 0.51 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.52
Under basal conditions, dopamine transporter knock-out mice show enhanced striatal DARPP-32 phosphorylation, activation of ERK, and inactivation of Akt as compared with wild-type littermates.
Phosphorylation (phosphorylation) of DARPP-32 associated with targeted disruption and dopamine
18) Confidence 0.49 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954211 Disease Relevance 0.61 Pain Relevance 0.46
Another useful approach to examine whether dopamine activity is heightened in neglectful mice is to examine the postsynaptic phosphorylational state of DARPP-32.
Phosphorylation (phosphorylational) of DARPP-32 associated with dopamine
19) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.44
LTP-inducing high-frequency stimulation has been reported to cause sustained DARPP-32 phosphorylation by PKA in a manner dependent on CaMKII in hippocampal slices (Atkins et al, 2005).
Phosphorylation (phosphorylation) of DARPP-32 associated with long-term potentiation
20) Confidence 0.40 Published 2009 Journal Mol Syst Biol Section Body Doc Link PMC2710870 Disease Relevance 0 Pain Relevance 0.12

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