INT11291

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Context Info
Confidence 0.61
First Reported 1986
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 5.93
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
arterioles 6
nucleus accumbens 2
sciatic nerve 2
fat 2
livers 2
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 12 99.98 Very High Very High Very High
tolerance 114 98.44 Very High Very High Very High
Sciatic nerve 18 97.32 Very High Very High Very High
Nucleus accumbens 4 97.16 Very High Very High Very High
Analgesic 3 94.84 High High
Endogenous opioid 1 94.40 High High
Hippocampus 1 92.92 High High
Calcitonin gene-related peptide 42 90.80 High High
Central nervous system 4 88.04 High High
hypoalgesia 6 83.64 Quite High
Disease Link Frequency Relevance Heat
Obesity 228 99.98 Very High Very High Very High
Hyperglycemia 18 99.36 Very High Very High Very High
Impaired Glucose Tolerance 120 98.44 Very High Very High Very High
Natriuresis 32 97.32 Very High Very High Very High
Stress 60 96.52 Very High Very High Very High
Diabetes Mellitus 54 95.60 Very High Very High Very High
Hyperlipidemia 12 94.56 High High
Urological Neuroanatomy 1 91.48 High High
Salivary Gland Disease 1 91.40 High High
Neuropathy 24 87.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.
Positive_regulation (enhanced) of Gene_expression (expression) of NEP in intestine
1) Confidence 0.61 Published 1992 Journal Experientia Section Abstract Doc Link 1547865 Disease Relevance 0.19 Pain Relevance 0.24
The coordinated changes (in some regions) of NEP and APN expression were opposite to those previously observed for PPII mRNA and activity levels in limbic regions.
Positive_regulation (observed) of Gene_expression (expression) of NEP
2) Confidence 0.42 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17952634 Disease Relevance 0.09 Pain Relevance 0.24
CONCLUSIONS: Rat hepatomas and a human hepatocarcinoma cell line express high amounts of NEP, in contrast to normal rat and human livers, which have very little.
Positive_regulation (amounts) of Gene_expression (express) of NEP in livers
3) Confidence 0.36 Published 1994 Journal Lab. Invest. Section Body Doc Link 8302012 Disease Relevance 0.05 Pain Relevance 0
Moreover, we found that expression and activity of neutral endopeptidase in epineurial arterioles was increased in high-fat fed rats.
Positive_regulation (increased) of Gene_expression (expression) of neutral endopeptidase in fat
4) Confidence 0.34 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 1.11 Pain Relevance 0.13
We have shown that diet-induced obesity causes an increase in the expression of neutral endopeptidase in epineurial arterioles [1].
Positive_regulation (causes) of Gene_expression (expression) of neutral endopeptidase in arterioles associated with obesity
5) Confidence 0.34 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 1.12 Pain Relevance 0.06
One of these mechanisms is the increased expression/activity of neutral endopeptidase [20].
Positive_regulation (increased) of Gene_expression (expression) of neutral endopeptidase
6) Confidence 0.25 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 0.96 Pain Relevance 0.03
Previously, we demonstrated that high-fat fed rats, a model for diet-induced obesity, develop microvascular and neural deficits independent of hyperglycemia and this was accompanied by an increase in the expression of neutral endopeptidase in epineurial arterioles, vessels that provide circulation to the sciatic nerve [1].
Positive_regulation (increase) of Gene_expression (expression) of neutral endopeptidase in sciatic nerve associated with hyperglycemia, obesity and sciatic nerve
7) Confidence 0.23 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 0.34 Pain Relevance 0.05
DIO is associated with increased expression of NEP in epineurial arterioles.
Positive_regulation (increased) of Gene_expression (expression) of NEP in arterioles associated with obesity
8) Confidence 0.23 Published 2011 Journal Journal of Obesity Section Abstract Doc Link PMC2933895 Disease Relevance 0.88 Pain Relevance 0.14
We have shown that diet-induced obesity causes an increase in the expression of neutral endopeptidase in epineurial arterioles [1].
Positive_regulation (increase) of Gene_expression (expression) of neutral endopeptidase in arterioles associated with obesity
9) Confidence 0.23 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 1.12 Pain Relevance 0.06
However, in neutrophils treated with a physiological (10(-10) M) concentration of MENK, two main events occurred; not only did the number of CD10 positive cells correlate with NEP activity, but contrary to control samples, MENK upregulated the expression of CD10 marker as demonstrated by an increase of mean florescence intensity (F-mean) in donors with low NEP activity.
Positive_regulation (upregulated) of Gene_expression (expression) of CD10 in neutrophils associated with enkephalin
10) Confidence 0.09 Published 2001 Journal Int. Immunopharmacol. Section Abstract Doc Link 11367540 Disease Relevance 0 Pain Relevance 0.64
Microinjection of the enkephalinase inhibitor thiorphan or the aminopeptidase inhibitor bestatin into the nucleus accumbens of the rabbit produced a dose-dependent analgesic effect.
Positive_regulation (Microinjection) of Gene_expression (Microinjection) of enkephalinase in nucleus accumbens associated with nucleus accumbens and analgesic
11) Confidence 0.02 Published 1986 Journal Brain Res. Section Abstract Doc Link 3489502 Disease Relevance 0 Pain Relevance 1.22

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