INT112914

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Context Info
Confidence 0.22
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.13
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Ppp1r1b, Prkaca) nucleus (Ppp1r1b, Prkaca) mitochondrion (Prkaca)
Golgi apparatus (Prkaca) intracellular (Ppp1r1b) protein complex (Prkaca)
Ppp1r1b (Mus musculus)
Prkaca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 143 98.52 Very High Very High Very High
Neurotransmitter 3 91.20 High High
Glutamate 35 90.84 High High
adenocard 2 87.36 High High
Opioid 1 85.52 High High
tetrodotoxin 1 85.36 High High
antagonist 5 77.72 Quite High
long-term potentiation 8 48.88 Quite Low
cocaine 5 44.80 Quite Low
Neuropeptide 2 37.92 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 74.56 Quite High
Stress 1 10.56 Low Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, neurotensin, by removing the inhibition of PKA by phospho-Thr75 DARPP-32, potentiates its signalling via the dopamine/D1 receptor/PKA/phospho-Thr34 DARPP-32/PP-1 cascade.
DARPP-32 Negative_regulation (inhibition) of PKA associated with dopamine
1) Confidence 0.22 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 12956723 Disease Relevance 0 Pain Relevance 0.33
When phosphorylated at Thr34, DARPP-32 is a potent inhibitor of PP1 [14], whereas when phosphorylated at Thr75 DARPP-32 inhibits protein kinase A (PKA) [15].
DARPP-32 Negative_regulation (inhibits) of PKA
2) Confidence 0.09 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.41
On the other hand, DARPP-32 becomes an inhibitor of PKA when it is phosphorylated on Thr75 by cyclin-dependent kinase 5 (Cdk5).
DARPP-32 Negative_regulation (inhibitor) of PKA
3) Confidence 0.06 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.13 Pain Relevance 0.12

General Comments

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