INT11292

Context Info Confidence 0.78 First Reported 1982 Last Reported 2011 Negated 5 Speculated 4 Reported most in Abstract Documents 77 Total Number 86 Disease Relevance 20.98 Pain Relevance 35.85

peptidase activity (Mme) plasma membrane (Mme)

Anatomy Link Frequency plasma 4 brain 4 nerve 4 median eminence 4 trachea 3 Mme (Rattus norvegicus)

Pain Link Frequency Relevance Heat opioid receptor 268 100.00 Enkephalin 182 100.00 substance P 138 100.00 Neuropeptide 51 100.00 analgesia 14 99.96 qutenza 55 99.72 Central nervous system 54 99.64 Analgesic 26 99.64 Pain 17 99.48 Opioid 114 99.38

Disease Link Frequency Relevance Heat Adhesions 1 100.00 Pain 16 99.48 Sprains And Strains 3 99.48 Obesity 229 99.46 Cancer 8 99.24 Pancreatitis 16 99.16 Hyperglycemia 21 99.04 Salivary Gland Disease 4 98.64 Inflammatory Pain 1 98.18 Impaired Glucose Tolerance 120 98.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A close relationship between enkephalinase inhibition expressed by IC50 in vitro and enhancement of morphine analgesia in vivo was observed in thirteen out of nineteen AHPA derivatives examined.

Gene_expression (expressed) of enkephalinase associated with analgesia and morphine

1) Confidence 0.78 Published 1982 Journal Life Sci. Section Abstract Doc Link 6124860 Disease Relevance 0 Pain Relevance 1.32

In tegmentum/colliculi a higher NEP gene expression in AA rats was associated with a higher NEP enzyme activity compared to the amounts found in ANA rats.

Gene_expression (expression) of NEP gene in tegmentum

2) Confidence 0.77 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9630637 Disease Relevance 0 Pain Relevance 0.37

Enkephalinase (EC 3.4.24.11, membrane metalloendopeptidase) is a zinc peptidase expressed by neurons and a variety of epithelial cells, and responsible for the inactivation of enkephalins in brain.

Gene_expression (expressed) of Enkephalinase in epithelial cells associated with enkephalin

3) Confidence 0.77 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1716743 Disease Relevance 0 Pain Relevance 0.10

A soil isolate of actinomycete, strain SANK 60684, was found to produce new enkephalinase B inhibitors, propioxatins A and B.

Gene_expression (produce) of enkephalinase B associated with sprains and strains

4) Confidence 0.72 Published 1986 Journal J. Antibiot. Section Abstract Doc Link 3536826 Disease Relevance 0.27 Pain Relevance 0

In addition, LPS-induced alterations in airway responses to bronchial constrictors, neutral endopeptidase (NEP) gene expression, leukocyte counts, and SP and calcitonin gene-related peptide (CGRP) levels were determined.

Gene_expression (expression) of NEP in leukocyte associated with calcitonin gene-related peptide

5) Confidence 0.71 Published 2003 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 12738685 Disease Relevance 0.06 Pain Relevance 0.27

In situ hybridization experiments on sections of the ganglia of the CNS revealed that apNEP is expressed in neurons and that the mRNA is present both in the cell bodies and in neurites that travel along the neuropil and peripheral nerves.

Gene_expression (expressed) of apNEP in neuropil

6) Confidence 0.70 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10341232 Disease Relevance 0.08 Pain Relevance 0.11

Detection of neutral endopeptidase (NEP, enkephalinase, E.C.3.4.24.11) in relation to dopaminergic and gonadoliberinergic nerve endings in the median eminence of the male rat: a double labeling ultrastructural study.

Gene_expression (Detection) of enkephalinase in nerve

7) Confidence 0.69 Published 1994 Journal J. Neuroendocrinol. Section Title Doc Link 7894468 Disease Relevance 0 Pain Relevance 0.34

Detection of neutral endopeptidase (NEP, enkephalinase, E.C.3.4.24.11) in relation to dopaminergic and gonadoliberinergic nerve endings in the median eminence of the male rat: a double labeling ultrastructural study.

Gene_expression (Detection) of NEP in nerve

8) Confidence 0.69 Published 1994 Journal J. Neuroendocrinol. Section Title Doc Link 7894468 Disease Relevance 0 Pain Relevance 0.34

On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.

Gene_expression (expression) of NEP in intestine

9) Confidence 0.68 Published 1992 Journal Experientia Section Abstract Doc Link 1547865 Disease Relevance 0.19 Pain Relevance 0.24

The fine structural distribution of the enzyme-neutral endopeptidase EC 3.4.24.11 (enkephalinase) was examined by immunoradioautography (using an iodinated monoclonal antibody) and peroxidase immunocytochemistry (using the same probe in nonradioactive form) in the neostriatum of the rat.

Gene_expression (distribution) of endopeptidase EC 3.4.24.11

10) Confidence 0.68 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2201754 Disease Relevance 0 Pain Relevance 0.03

The fine structural distribution of the enzyme-neutral endopeptidase EC 3.4.24.11 (enkephalinase) was examined by immunoradioautography (using an iodinated monoclonal antibody) and peroxidase immunocytochemistry (using the same probe in nonradioactive form) in the neostriatum of the rat.

Gene_expression (distribution) of enkephalinase

11) Confidence 0.68 Published 1990 Journal J. Neurosci. Section Abstract Doc Link 2201754 Disease Relevance 0 Pain Relevance 0.03

Neutral endopeptidase 24.11 (NEP) and angiotensin-converting enzyme (ACE) degrade neuropeptides, including enkephalin and are expressed in the brain.

Gene_expression (expressed) of Neutral endopeptidase 24.11 in brain associated with neuropeptide and enkephalin

12) Confidence 0.68 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9630637 Disease Relevance 0.07 Pain Relevance 0.79

Neutral endopeptidase (NEP, enkephalinase, CALLA) which is present in various neural and non-neural tissues, is able to cleave a variety of regulatory peptides.

Gene_expression (present) of NEP in neural

13) Confidence 0.67 Published 1992 Journal Experientia Section Abstract Doc Link 1547865 Disease Relevance 0 Pain Relevance 0.17

These observations suggest that inhibitors of enkephalinase A produce analgesia through a pharmacological mechanism which is not directly related to inhibition of enkephalin degradation.

Gene_expression (produce) of enkephalinase associated with enkephalin and analgesia

14) Confidence 0.67 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3894620 Disease Relevance 0 Pain Relevance 0.78

The neuropeptides are degraded by peptidases, e.g., neutral endopeptidase (NEP) that is present in the nasal mucosa.

Gene_expression (present) of NEP in nasal mucosa associated with neuropeptide

15) Confidence 0.67 Published 1998 Journal Am J Rhinol Section Abstract Doc Link 9578933 Disease Relevance 0 Pain Relevance 0.62

In most areas of the central nervous system, the cell types which express NEP activity are not known.

Gene_expression (express) of NEP in central nervous system associated with central nervous system

16) Confidence 0.67 Published 1994 Journal J. Comp. Neurol. Section Abstract Doc Link 8201016 Disease Relevance 0.05 Pain Relevance 0.39

[Role of aminopeptidases in enkephalin catabolism: comparative study of the regional distribution of aminopeptidases and enkephalinase A in the rat brain].

Gene_expression (distribution) of enkephalinase in brain associated with enkephalin

17) Confidence 0.67 Published 1990 Journal Biokhimiia Section Title Doc Link 1981849 Disease Relevance 0 Pain Relevance 0.59

[Enkephalinase inhibitors and molecular study of the differences between active sites of enkephalinase and angiotensin-converting enzyme].

Gene_expression (sites) of enkephalinase associated with analgesic

18) Confidence 0.66 Published 1985 Journal J Pharmacol Section Title Doc Link 2993752 Disease Relevance 0 Pain Relevance 0.85

New orally active enkephalinase inhibitors: their synthesis, biological activity, and analgesic properties.

Gene_expression (synthesis) of enkephalinase associated with analgesic

19) Confidence 0.66 Published 1998 Journal Bioorg. Med. Chem. Section Title Doc Link 9597188 Disease Relevance 0 Pain Relevance 0.68

The coordinated changes (in some regions) of NEP and APN expression were opposite to those previously observed for PPII mRNA and activity levels in limbic regions.

Gene_expression (expression) of NEP

20) Confidence 0.65 Published 2007 Journal J. Mol. Neurosci. Section Abstract Doc Link 17952634 Disease Relevance 0.09 Pain Relevance 0.24

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